TBI—the most complex disease in the most complex organ: the CENTER-TBI trial—a commentary

Each year, approximately 2.5 million people experience some form of traumatic brain injury (TBI) in Europe. One million of these are admitted to hospital and 75 000 will die. TBI represents a major cause of death and disability, particularly among those of working age. Substantial investments have b...

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Bibliographic Details
Published in:BMJ military health 2016-04, Vol.162 (2), p.87-89
Main Authors: Wheble, Joanna L C, Menon, D K
Format: Article
Language:English
Subjects:
Biomarkers
Brain Injuries - diagnosis
Brain Injuries - therapy
Classification
Coma
Datasets
Europe
Humans
Intervention
Neuroimaging
Observational Studies as Topic
Prognosis
Registries
Studies
Traumatic brain injury
Citations: Items that this one cites
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Summary:Each year, approximately 2.5 million people experience some form of traumatic brain injury (TBI) in Europe. One million of these are admitted to hospital and 75 000 will die. TBI represents a major cause of death and disability, particularly among those of working age. Substantial investments have been made in an effort to improve diagnosis, management and survival in TBI, but with little success. The Collaborative European Neuro-Trauma Effectiveness Research in TBI (CENTER-TBI) study promises to use the natural variability seen in the management of TBI across Europe with the application of Comparative Effectiveness Research (CER). It will generate repositories of baseline and comprehensive TBI patient data, neuroimaging, neurogenetics and biomarkers, which aim to improve the diagnosis, stratification, management and prognostication of patients with TBI.
ISSN:0035-8665
2633-3767
2052-0468
2633-3775
DOI:10.1136/jramc-2015-000472