Copper(I)-Catalyzed 3-Position Methylation of Coumarins by Using Di-tert-butyl Peroxide as the Methylation Reagents

The copper‐catalyzed methylation of coumarin by using di‐tert‐butyl peroxide (DTBP) has been described. The reaction provides direct access to a wide range of 3‐methylcoumarins in moderate to good yields. In this procedure, it is noteworthy that DTBP was employed not only as the oxidant, but also as...

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Bibliographic Details
Published in:Chinese journal of chemistry 2016-04, Vol.34 (4), p.368-372
Main Authors: Zhuang, Huan, Zeng, Runsheng, Zou, Jianping
Format: Article
Language:English
Subjects:
coumarin
CuCl
di-tert-butyl peroxide
methylation
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Summary:The copper‐catalyzed methylation of coumarin by using di‐tert‐butyl peroxide (DTBP) has been described. The reaction provides direct access to a wide range of 3‐methylcoumarins in moderate to good yields. In this procedure, it is noteworthy that DTBP was employed not only as the oxidant, but also as the methyl source. The copper‐catalyzed methylation of coumarin by using di‐tert‐butyl peroxide (DTBP) has been described. The reaction provides direct access to a wide range of 3‐methylcoumarins in moderate to good yields. In this procedure, it is noteworthy that DTBP was employed not only as the oxidant, but also as the methyl source.
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.201500836