A New Synthetic Framework for 11-Demethylellipticine

A new synthetic route for the synthesis of 5‐methyl‐6H‐pyrido[4,3‐b]carbazole (8), so‐called 11‐demethylellipticine, was described. Construction of the tetracyclic structure hexahydro‐1H‐pyrido[4,3‐b]carbazol‐5(6H)‐one skeleton (6) was also achieved by nucleophilic substitution reaction in the synth...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2016-05, Vol.53 (3), p.767-770
Main Authors: Gocmenturk, Mustafa, Gundodu Hizliates, Cevher, Ergun, Yavuz
Format: Article
Language:English
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Summary:A new synthetic route for the synthesis of 5‐methyl‐6H‐pyrido[4,3‐b]carbazole (8), so‐called 11‐demethylellipticine, was described. Construction of the tetracyclic structure hexahydro‐1H‐pyrido[4,3‐b]carbazol‐5(6H)‐one skeleton (6) was also achieved by nucleophilic substitution reaction in the synthetic route. Also new tetrahydrocarbazole derivatives (2, 3, 4, and 5) were synthesized. Several ellipticine analogs and octahydropyridocarbazole‐based G‐protein coupled receptors inhibitors can also be synthesized from tetracyclic structure (6) because of carbonyl functionality at position 5.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.2366