Clear cell renal cell carcinoma with osseous metaplasia: Rare case report

Osseous metaplasia with clear cell renal cell carcinoma (RCC) is exceedingly rare. There are less than 20 reported cases of osseous metaplasia in association with RCC. We present a case of 39-year-old male patient presented to outpatient department with complaints of pain in the left lumbar region s...

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Bibliographic Details
Published in:Journal of cancer research and therapeutics 2015-10, Vol.11 (4), p.1039
Main Authors: Agarwal, Swapnil, Bohara, Sangita, Jha, Ruchi, Khurana, Nita, Agarwal, P N
Format: Article
Language:English
Subjects:
Adult
Bone Diseases - complications
Bone Diseases - pathology
Bone Diseases - surgery
Bone tumors
Calcinosis - complications
Calcinosis - pathology
Calcinosis - surgery
Carcinoma, Renal Cell - complications
Carcinoma, Renal Cell - pathology
Carcinoma, Renal Cell - surgery
Care and treatment
Case studies
Diagnosis
Humans
Kidney Neoplasms - complications
Kidney Neoplasms - pathology
Kidney Neoplasms - surgery
Male
Metaplasia
Metaplasia - complications
Metaplasia - pathology
Metaplasia - surgery
Nephrectomy
Prognosis
Rare Diseases - pathology
Rare Diseases - surgery
Renal cell carcinoma
Tomography, X-Ray Computed
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Summary:Osseous metaplasia with clear cell renal cell carcinoma (RCC) is exceedingly rare. There are less than 20 reported cases of osseous metaplasia in association with RCC. We present a case of 39-year-old male patient presented to outpatient department with complaints of pain in the left lumbar region since 4 years. Computed tomography scan revealed a heterogeneous enhanced mass lesion having areas of necrosis and specks of calcification involving the left kidney. Clinicoradiological diagnosis of RCC was made and left radical nephrectomy was performed. Histological sections from the growth revealed features of clear cell carcinoma Fuhrman grade-2 with a focal area of metaplastic bone formation. The prognostic implications of calcification per se are not very clearly mentioned in the literature. Patients with osseous metaplasia generally present with early stage disease and a favorable prognosis. However, few of them were of high grade and poorer prognosis.
ISSN:0973-1482
1998-4138
DOI:10.4103/0973-1482.146109