Intravenous immunoglobulin up-regulates the expression of the inhibitory Fc[gamma]IIB receptor on B cells

Intravenous immunoglobulin (IVIg) preparations are known to modulate autoimmune/inflammatory diseases through several F(ab')2 - and Fc-dependent mechanisms. In this study, we show that the in vitro and the in vivo exposure of B lymphocytes from lupus-prone and from healthy mice to IVIg results...

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Bibliographic Details
Published in:Immunology and cell biology 2009-10, Vol.87 (7), p.529
Main Authors: Nikolova, Kalina A, Tchorbanov, Andrey I, Djoumerska-alexieva, Iglika K, Nikolova, Maria, Vassilev, Tchavdar L
Format: Article
Language:English
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Summary:Intravenous immunoglobulin (IVIg) preparations are known to modulate autoimmune/inflammatory diseases through several F(ab')2 - and Fc-dependent mechanisms. In this study, we show that the in vitro and the in vivo exposure of B lymphocytes from lupus-prone and from healthy mice to IVIg results in an increased expression of their surface inhibitory FcγIIB receptors. Further, this exposure enhanced the ability of a chimeric antibody, cross-linking FcγRIIB and immunoglobulin receptors on DNA-specific B lymphocytes, to suppress IgG anti-DNA antibody production. F(ab') 2 fragments of IVIg had a similar activity as the intact preparation, whereas Fc fragments had no effect. This study describes a novel approach with clinical relevance for modulating B lymphocyte activity.
ISSN:0818-9641
1440-1711
DOI:10.1038/icb.2009.36