Polymeric nanocomposite: Development, characterization, ex vivo and in vivo evaluation for ulcerative colitis

Chitosan nanoparticles (CH-NPs) and chitosan-montmorillonite nanocomposites (CH-MMT-NCPs) were developed and characterized. The in vitro drug release data revealed that the CH-MMT-NCPs successfully retarded the drug release until it entered into the simulated colonic fluid. Experimental colitis was...

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Bibliographic Details
Published in:International journal of polymeric materials 2016-05, Vol.65 (7), p.337-350
Main Authors: Gulbake, Arvind, Chashoo, Gousia, Sharma, P. R., Gupta, Prem N., Saxena, A. K., Jain, Sanjay K.
Format: Article
Language:English
Subjects:
Chitosan
Clay
Inflammatory bowel disease
montmorillonite
nanocomposite
Nanocomposites
Polymers
ulcerative colitis
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Summary:Chitosan nanoparticles (CH-NPs) and chitosan-montmorillonite nanocomposites (CH-MMT-NCPs) were developed and characterized. The in vitro drug release data revealed that the CH-MMT-NCPs successfully retarded the drug release until it entered into the simulated colonic fluid. Experimental colitis was induced by trinitrobenzenesulfonic acid (TNBS) into albino rats and clinical activity score and histological evaluation revealed that the CH-MMT-NCPs markedly improved the healing efficacy as compare to CH-NPs and drug solution. The CH-MMT-NCPs showed remarkable reduction in the ulcer index (3.80 ± 0.54) as compared to the CH-NPs (7.03 ± 0.78) and the group received MSZ solution (9.85 ± 0.58), respectively.
ISSN:0091-4037
1563-535X
DOI:10.1080/00914037.2015.1119690