Heat killed Saccharomyces cerevisiae as an adjuvant for the induction of vaccine-mediated immunity against infection with Mycobacterium tuberculosis

Highlights • First studies to demonstrate the effective use of a Mycobacterium tuberculosis antigen expressing recombinant heat-killed yeast vaccine. • The recombinant heat-killed yeast vaccine induced CD4+ and CD8+ T cell immunity. • The recombinant heat-killed yeast can be used to boost BCG induce...

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Bibliographic Details
Published in:Vaccine 2016-05, Vol.34 (25), p.2798-2805
Main Authors: Grover, Ajay, McLean, Jennifer L, Troudt, JoLynn M, Foster, Chad, Izzo, Linda, Creissen, Elisabeth, MacDonald, Elisabeth, Troy, Amber, Izzo, Angelo A
Format: Article
Language:English
Subjects:
Acyltransferases - immunology
Adjuvants, Immunologic - administration & dosage
Allergy and Immunology
Animal models
Animals
Antigens
Antigens, Bacterial - immunology
Bacterial Proteins - immunology
Cancer
Cloning
Cytokines - immunology
Female
Hot Temperature
Immune response
Immunization, Secondary
Infections
Laboratory animals
Mice, Inbred C57BL
Mycobacterium tuberculosis
Proteins
Recombinant heat killed yeast vaccine
Recombinant Proteins - immunology
Rodents
Saccharomyces cerevisiae - immunology
Studies
T-Lymphocytes - immunology
Tuberculosis
Tuberculosis - prevention & control
Tuberculosis Vaccines - immunology
Vaccines
Viral infections
Yeast
Yeasts
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Summary:Highlights • First studies to demonstrate the effective use of a Mycobacterium tuberculosis antigen expressing recombinant heat-killed yeast vaccine. • The recombinant heat-killed yeast vaccine induced CD4+ and CD8+ T cell immunity. • The recombinant heat-killed yeast can be used to boost BCG induced immunity.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2016.04.052