Effectiveness of the live attenuated rotavirus vaccine produced by a domestic manufacturer in China studied using a population-based case-control design

A universal rotavirus (RV) immunization program is a potentially cost-effective measure for preventing RV infection in China. However, the efficacy of the only licensed RV vaccine (Lanzhou lamb rotavirus vaccine, LLR), which is made by a domestic manufacturer, has not been proven by a properly desig...

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Bibliographic Details
Published in:Emerging microbes & infections 2015-10, Vol.4 (1), p.1-6
Main Authors: Zhen, Shan-Shan, Li, Yue, Wang, Song-Mei, Zhang, Xin-Jiang, Hao, Zhi-Yong, Chen, Ying, Wang, Dan, Zhang, Yan-Hong, Zhang, Zhi-Yong, Ma, Jing-Chen, Zhou, Peng, Zhang, Zhen, Jiang, Zhi-Wei, Zhao, Yu-Liang, Wang, Xuan-Yi
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
attenuated vaccine
Case-Control Studies
case-control study
Child, Preschool
China
Cohort Studies
Diarrhea
Diarrhea - prevention & control
Diarrhea - virology
effectiveness
Feces - virology
Gastroenteritis
Gastroenteritis - prevention & control
Gastroenteritis - virology
Genotyping Techniques
Humans
Immunization
Infant
Odds Ratio
Original
Population Surveillance
Population-based studies
Rotavirus
Rotavirus - classification
Rotavirus - genetics
Rotavirus - isolation & purification
Rotavirus Infections - prevention & control
Rotavirus Infections - virology
Rotavirus Vaccines - administration & dosage
Rotavirus Vaccines - standards
Severity of Illness Index
Sheep
Surveys and Questionnaires
Vaccines
Vaccines, Attenuated - administration & dosage
Vaccines, Attenuated - standards
Viruses
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Summary:A universal rotavirus (RV) immunization program is a potentially cost-effective measure for preventing RV infection in China. However, the efficacy of the only licensed RV vaccine (Lanzhou lamb rotavirus vaccine, LLR), which is made by a domestic manufacturer, has not been proven by a properly designed clinical trial. In October 2011 to March 2012, to measure the potential protection provided by LLR, a case-control study nested in a population-based active diarrhea surveillance study of children
ISSN:2222-1751
2222-1751
DOI:10.1038/emi.2015.64