Effect of the Ingestion of Low-molecular-weight Anticoagulant on the Progression of Induced Periodontitis in Rats

• Published in: Journal of international oral health 2016-05, Vol.8 (5), p.536
• Main Authors: Segundo, Alex Semenoff, Borges, Álvaro Henrique, Porto, Alessandra Nogueira, Bandeca, Matheus Coelho, Diniz, Ana Carolina Soares, de Lima, Ana Paula da Cunha Barbosa, Buzelle, Samyra Lopes, Semenoff, Tereza A Delle Vedove
• Format: Article
• Language: English
• Subjects: Acute coronary syndromes; Animals; Anticoagulants; Bone surgery; Dentists; Disease; Experiments; Growth factors; Rodents; Studies; Tumor necrosis factor-TNF
• ISSN: 0976-7428; 0976-1799
• DOI: 10.2047/jioh-08-05-02

The aim of this article is to assess whether the administration of low-molecular-weight anticoagulant (LMWA) is able to interfere with the progression of bone loss in experimental ligature-induced periodontitis in rats. 48 rats were randomly divided into four groups of equal numbers (n = 12). The first group received only LMWA-heparin (HG); the second one had periodontal disease induced (LG); the third one was the combination of heparin and induced periodontitis (HLG), and the fourth and last group was the control (CG) - nothing was done. Heparin (600 IU/kg/day) was administered subcutaneous from the first day of the experiment for the groups HG and HLG and remained for 30 days. Periodontitis was induced in maxillary right second molar on groups LG and HLG 15 days after the beginning of the experiment and remained for 15 days longer. The bone loss in left and right maxillaries was radiographic compared between groups. To bone loss, the findings show that the left side without induction of periodontal disease showed the lowest radiographic bone loss with no significant differences between groups (P > 0.05). On the side where disease was induced, HLG presented the highest radiographic bone loss in relation to the other groups (P < 0.05), followed by LG (P < 0.05) and CG and GH with no differences between them (P > 0.05). In comparisons between the right side (with induction of disease) and the left side (without induction of disease), there were differences for all comparisons (P > 0.05), excepting the one between HG and CG. Rats undergoing heparin therapy tests had greater bone loss after induction of ligature-induced periodontitis.