Effects of iron oxide nanoparticles on biological responses and MR imaging properties in human mammary healthy and breast cancer epithelial cells

Superparamagnetic iron oxide nanoparticles (SPIONs, diameters >50 nm) have received great attention due to their promising use as magnetic resonance imaging (MRI) contrast agents. In this study, we evaluated the cellular uptake and biological responses in vitro of ultrasmall SPIONs (USPIONs, diam...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2016-07, Vol.104 (5), p.1032-1042
Main Authors: Zhang, Qin, Rajan, Sunder S., Tyner, Katherine M., Casey, Brendan J., Dugard, Christopher K., Jones, Yvonne, Paredes, Angel M., Clingman, Chekesha S., Howard, Paul C., Goering, Peter L.
Format: Article
Language:English
Subjects:
Biomedical materials
breast epithelial cells
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - metabolism
Cell Line, Tumor
Coated Materials, Biocompatible - chemistry
Coated Materials, Biocompatible - pharmacology
contrast agents
Contrast Media - chemistry
Contrast Media - pharmacology
Female
Ferric Compounds - chemistry
Ferric Compounds - pharmacology
Humans
iron oxide
Magnetic Resonance Imaging
Mammary Glands, Human - diagnostic imaging
Mammary Glands, Human - metabolism
Materials research
Materials science
nanoparticles
Nanoparticles - chemistry
Polyethylene Glycols - chemistry
Polyethylene Glycols - pharmacology
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Summary:Superparamagnetic iron oxide nanoparticles (SPIONs, diameters >50 nm) have received great attention due to their promising use as magnetic resonance imaging (MRI) contrast agents. In this study, we evaluated the cellular uptake and biological responses in vitro of ultrasmall SPIONs (USPIONs, diameters 
ISSN:1552-4973
1552-4981
DOI:10.1002/jbm.b.33450