Long noncoding RNAs in regulation of human breast cancer

Less than 2% of the human genome DNA is composed of protein-coding genes, although the majority of the human genome is transcribed, indicating the transcripts mostly are noncoding RNAs. Those noncoding RNAs with length between 200 nt and 200 kb are categorized as long noncoding RNA (lncRNA). Around...

Full description

Saved in:
Bibliographic Details
Published in:Briefings in functional genomics & proteomics 2016-05, Vol.15 (3), p.222
Main Authors: Wang, Guangxue, Liu, Cuicui, Deng, Shengqiong, Zhao, Qian, Li, Tieyan, Qiao, Shanshan, Shen, Lei, Zhang, Yue, Lü, Jinhui, Meng, Lingyu, Liang, Chunli, Yu, Zuoren
Format: Article
Language:English
Subjects:
Breast cancer
Deoxyribonucleic acid
DNA
Genomes
Medical treatment
Proteins
Ribonucleic acid
RNA
Tumors
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Less than 2% of the human genome DNA is composed of protein-coding genes, although the majority of the human genome is transcribed, indicating the transcripts mostly are noncoding RNAs. Those noncoding RNAs with length between 200 nt and 200 kb are categorized as long noncoding RNA (lncRNA). Around 30 000 lncRNAs have been predicted or identified, although little is known regarding the regulatory function for a vast majority of these sequences. Emerging evidence demonstrated that lncRNAs play crucial roles in regulation of many cancer types, including breast cancer, serving as oncogenes or tumor suppressors. Aberrant and differential expression of lncRNA in breast cancer has been frequently reported. Their regulation of breast cancer is still the beginning to be elucidated. This review collected those experimentally validated lncRNAs in human breast cancer, summarizing their biological function as well as the regulatory mechanism. In addition, the potential of lncRNAs as biomarkers for better diagnosis or therapeutic targets for cancer treatment was discussed.
ISSN:2041-2649
2041-2657