Hierarchical nanostructures of Au@ZnO: antibacterial and antibiofilm agent

The perpetual use of antibiotics against pathogens inadvertently altered their genes that have translated into an unprecedented resistance in microorganisms in the twenty-first century. Many researchers have formulated bactericidal and bacteriostatic inorganic nanoparticle-based antiseptics that may...

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Bibliographic Details
Published in:Applied microbiology and biotechnology 2016-07, Vol.100 (13), p.5849-5858
Main Authors: Gholap, Haribhau, Warule, Sambhaji, Sangshetti, Jaiprakash, Kulkarni, Gauri, Banpurkar, Arun, Satpute, Surekha, Patil, Rajendra
Format: Article
Language:English
Subjects:
Analysis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibiotics
Antimicrobial agents
Applied Genetics and Molecular Biotechnology
Aqueous solutions
Biofilms
Biofilms - drug effects
Biomedical and Life Sciences
Biotechnology
Dilution
Efficiency
Genetics
Gold
Gold - chemistry
Gold - pharmacology
Health aspects
Life Sciences
Metal oxides
Microbial Genetics and Genomics
Microbial Sensitivity Tests
Microbiology
Microorganisms
Nanomaterials
Nanoparticles
Nanostructures - chemistry
Nanostructures - microbiology
Nanostructures - toxicity
Nitrates
Pathogens
Physics
Scanning electron microscopy
Spectrum analysis
Stainless steel
Staphylococcus aureus - drug effects
Staphylococcus aureus - physiology
Studies
Zinc oxide
Zinc Oxide - chemistry
Zinc Oxide - pharmacology
Zinc oxides
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Summary:The perpetual use of antibiotics against pathogens inadvertently altered their genes that have translated into an unprecedented resistance in microorganisms in the twenty-first century. Many researchers have formulated bactericidal and bacteriostatic inorganic nanoparticle-based antiseptics that may be linked to broad-spectrum activity and far lower propensity to induce microbial resistance than organic-based antibiotics. Based on this line, herein, we present observations on microbial abatement using gold-based zinc oxide nanostructures (Au@ZnO) which are synthesized using hydrothermal route. Inhibition of microbial growth and biofilm using Au@ZnO is a unique feature of our study. Furthermore, this study evinces antimicrobial and antibiofilm mechanisms of photo-eradiated Au@ZnO by disruption of cellular functions and biofilms via reactive oxygen species (ROS)-dependent generation of superoxide anion radical. The present study is significant as it introduces novel functionalities to Au@ZnO in the biomedical field which can be extended to other species of microbial pathogens.
ISSN:0175-7598
1432-0614
DOI:10.1007/s00253-016-7391-1