A Rapid and Additive-Free Ruthenium-Catalyzed Reductive Amination of Aromatic Aldehydes

The ruthenium complex [(η6‐cymene)Ru(Cl)(dpmpy)]+ {dpmpy = 2‐[2‐(dimethylamino)pyrimidin‐4‐yl]pyridine} is highly reactive in catalyzing the reductive amination of aromatic aldehydes through in situ generated imines with 2‐propanol as the hydrogen source following a transfer‐hydrogenation mechanism....

Full description

Saved in:
Bibliographic Details
Published in:European journal of organic chemistry 2016-06, Vol.2016 (18), p.3060-3064
Main Authors: Kerner, Christian, Straub, Sascha-Dominic, Sun, Y., Thiel, Werner R.
Format: Article
Language:English
Subjects:
Aldehydes
Amination
Homogeneous catalysis
Hydrogenation
Reduction
Ruthenium
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The ruthenium complex [(η6‐cymene)Ru(Cl)(dpmpy)]+ {dpmpy = 2‐[2‐(dimethylamino)pyrimidin‐4‐yl]pyridine} is highly reactive in catalyzing the reductive amination of aromatic aldehydes through in situ generated imines with 2‐propanol as the hydrogen source following a transfer‐hydrogenation mechanism. This transformation does not require any activating additives and is applicable to a broad variety of aldehydes. A 2‐[2‐(dimethylamino)pyrimidin‐4‐yl]pyridine‐coordinated ruthenium complex catalyzes the reductive amination of aromatic aldehydes in the absence of any activating additives with high reaction rates, allowing the conversion of a broad scope of substrates.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201600515