Plant-Derived Urease Inhibitors as Alternative Chemotherapeutic Agents

• Published in: Archiv der Pharmazie (Weinheim) 2016-07, Vol.349 (7), p.507-522
• Main Authors: Hassan, Sherif T. S., Žemlička, Milan
• Format: Article
• Language: English
• Subjects: Anti-Ulcer Agents - analysis; Anti-Ulcer Agents - isolation & purification; Anti-Ulcer Agents - pharmacology; Antiulcer drugs; Bacteria - enzymology; Bioactive compounds; Gastric and urinary infections; Herbal plants; Humans; Plants - enzymology; Prescription drugs; Structure-Activity Relationship; Urease - antagonists & inhibitors; Urease inhibitors
• ISSN: 0365-6233; 1521-4184
• DOI: 10.1002/ardp.201500019

Inhibition of the metalloenzyme urease has important pharmacologic applications in the field of antiulcer and antigastric cancer agents. Urease is involved in many serious infections caused by Helicobacter pylori in the gastric tract as well as by Proteus and related species in the urinary tract. Although numerous studies have described several novel urease inhibitors (UIs) used for the treatment of gastric and urinary infections, all these compounds have exhibited severe side effects, toxicity, and instability. Therefore, to overcome such problems, it is necessary to search for new sources of UIs, such as natural products, that provide reduced side effects, low toxicity, greater stability, and bioavailability. As limited studies have been conducted on plant‐derived UIs, this paper aims to highlight and summarize the most promising compounds isolated and identified from plants, such as terpenoids, phenolic compounds, alkaloids, and other substances with inhibitory activities against plant and bacterial ureases; these are in vitro and in vivo studies with an emphasis on structure–activity relationship studies and types of inhibition that show high and promising levels of anti‐urease activity. This will aid medicinal chemists in the design and synthesis of novel and pharmacologically potent UIs useful for the development of antiulcer drugs. This review aims to highlight the most promising compounds isolated and identified from plants with inhibitory activities against plant and bacterial ureases, such as terpenoids, phenolic compounds, alkaloids, and other substances. This overview will aid medicinal chemists in the design and synthesis of novel and pharmacologically potent urease inhibitors for the development of antiulcer drugs.