A Comparative Study of the Clinical Efficacy of Lycopene and Curcumin in the Treatment of Oral Submucous Fibrosis using Ultrasonography

Oral submucous fibrosis (OSMF) is a chronic condition of the oral mucosa that has been largely reported among Indians and to lesser extent in other Asian people and other countries. There has been no satisfactory treatment for OSMF. The aim of this study is to measure the submucosal layer thickness...

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Bibliographic Details
Published in:Journal of international oral health 2016-11, Vol.8 (6), p.687
Main Authors: Kopuri, Rajiv Chowdary, Chakravarthy, Chitra, Sunder, Sanjay, Patil, Ravi, Shivaraj, W, Arakeri, Gururaj
Format: Article
Language:English
Subjects:
Antioxidants
Care and treatment
Chronic illnesses
Comparative analysis
Fibrosis
Health aspects
Lycopene
Mouth
Mouth diseases
Pain
Patients
Studies
Testing
Turmeric
Ultrasonic waves
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Summary:Oral submucous fibrosis (OSMF) is a chronic condition of the oral mucosa that has been largely reported among Indians and to lesser extent in other Asian people and other countries. There has been no satisfactory treatment for OSMF. The aim of this study is to measure the submucosal layer thickness using ultrasonography during the treatment of OSMF with lycopene and curcumin over a period of 3-month. Based on inclusion and exclusion criteria, 30 study subjects were included in the study. The patients have signed an informed consent before the start of the study. Patients under Group A (n = 15) were given lycopene 8 mg/day in 2 divided doses prescribed for 3 months. Patients under Group B were given curcumin 800 mg/day in 2 divided doses prescribed for 3 months. A clinical examination was carried out at every recall visit and the findings compared with those at the beginning of the treatment. The results were analyzed with unpaired t-test, Chi-square test, and ANOVA test. At 3-month follow-up, all the patients in both groups showed significant improvement in mouth opening and severity of burning sensation and blanching. When measured using ultrasound, a decrease in the thickness of fibrous bands was noticed in all patients in Group A and Group B. Lycopene is better when compared to curcumin in the treatment of OSMF, but studies with larger sample and longterm follow-up are needed for better understanding of curcumin in the treatment of OSMF.
ISSN:0976-7428
0976-1799
DOI:10.2047/jioh-08-06-09