SSynthesis, characterisation and antimicrobial-activity of 3-thio-1,5-dihydro-2,4,3-benzodioxaphosphepin-3-amino acid esters

A new series of 3-thio-1,5-dihydro-2,4,3-benzodioxaphosphepin-3-amino acid esters (4a-k) were synthesized by treating different amino acid ester hydrochlorides (3a-k) with phosphorus monochloride intermediate (2) which was previously formed in situ from 1,2-phenylenedimethanol (1) and thiophosphoryl...

Full description

Saved in:
Bibliographic Details
Published in:Organic communications 2011-07, Vol.4 (3), p.67
Main Authors: Chinthaparthi, Radha Rani, Gangireddy Chandra Sekhar Reddy, Chereddy, Syama Sundar, Kunda Uma Maheswara Rao, Krishnammagari, Suresh Kumar, Cirandur Suresh Reddy
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A new series of 3-thio-1,5-dihydro-2,4,3-benzodioxaphosphepin-3-amino acid esters (4a-k) were synthesized by treating different amino acid ester hydrochlorides (3a-k) with phosphorus monochloride intermediate (2) which was previously formed in situ from 1,2-phenylenedimethanol (1) and thiophosphoryl chloride in the presence of triethylamine in dry tetrahydrofuran (THF) at 0-5 ºC to room temperature. The structures of the title compounds (4a-k) were established by analytical, IR, NMR (1H, 13C and 31P) and mass spectra, and they have been screened for their antimicrobial activity. They exhibited significant antibacterial, and antifungal activity.
ISSN:1307-6175