Synthesis and antibacterial activity studies of novel 2-substituted-1,3,2-oxazaphosphole-2-oxide derivatives of (S)-(+)-prolinol

The novel 2-substituted-1,3,2-oxazaphosphole-2-oxides of (S)-(+)-prolinol were synthesized by the cyclization of (S)-(+)-prolinol (3) with phosphorusoxychloride (4) followed by the treatment with various phenolic compounds, aminoacid esters and amine (6a-l) to obtain the title compounds (7a-l). Thei...

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Bibliographic Details
Published in:Organic communications 2010-10, Vol.3 (4), p.98
Main Authors: B Satheesh Krishna, Rao, A Janardhan, K Reddi Mohan Naidu, V Koteswara Rao, C Naga Raju
Format: Article
Language:English
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Summary:The novel 2-substituted-1,3,2-oxazaphosphole-2-oxides of (S)-(+)-prolinol were synthesized by the cyclization of (S)-(+)-prolinol (3) with phosphorusoxychloride (4) followed by the treatment with various phenolic compounds, aminoacid esters and amine (6a-l) to obtain the title compounds (7a-l). Their structures are characterized by spectral, elemental analyses and evaluated their in vitro antibacterial activity against two gram positive and two gram negative bacteria. Three compounds exhibited very significant anti bacterial activity when compared with that of Ciprofloxacin.
ISSN:1307-6175