Three New Pregnane Alkaloids from Pachysandra terminalis

Three new pregnane alkaloids, pachystermine C (1), pachysanamine A (2), and pachysanamine B (3), together with four known ones, pachystermine B (4), pachysamine A (5), (20S)‐20‐(dimethylamino)‐16α‐hydroxy‐3β‐(3′α‐isopropyl)lactam‐5α‐pregnan‐4‐one (6), and E‐salignone (7), were isolated from Pachysan...

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Published in:Helvetica chimica acta 2016-07, Vol.99 (7), p.513-517
Main Authors: Sun, Yun, Chen, Jin-Xiong, Chen, Jian-Chao, Li, Zhong-Rong, Zhou, Lin, Li, Yan, Qiu, Ming-Hua
Format: Article
Language:English
Subjects:
Buxaceae
Cytotoxicity
Pachysandra terminalis
Pregnane alkaloids
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container_title Helvetica chimica acta
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creator Sun, Yun
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Li, Yan
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description Three new pregnane alkaloids, pachystermine C (1), pachysanamine A (2), and pachysanamine B (3), together with four known ones, pachystermine B (4), pachysamine A (5), (20S)‐20‐(dimethylamino)‐16α‐hydroxy‐3β‐(3′α‐isopropyl)lactam‐5α‐pregnan‐4‐one (6), and E‐salignone (7), were isolated from Pachysandra terminalis. The chemical structures of the new alkaloids were elucidated by spectroscopic methods. All the compounds were evaluated for their inhibitory activities against HL‐60, SMMC‐7721, A‐549, MCF‐7, and SW480 cell lines, some of the compounds showed stronger cytotoxicity for the test cell lines, especially compounds 2, 3, and 7.
doi_str_mv 10.1002/hlca.201600016
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subjects Buxaceae
Cytotoxicity
Pachysandra terminalis
Pregnane alkaloids
title Three New Pregnane Alkaloids from Pachysandra terminalis
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