Baeckeins J and K, Two Novel C-Methylated Biflavonoids from the Roots of Baeckea frutescens and Their Cytoprotective Activities

Baeckea frutescens is an aromatic shrub used as ornamentals and as food flavor spices in the southern part of P. R. China. Two novel C‐methylated biflavonoids named baeckeins J (1) and K (2) were isolated from the roots of B. frutescens, which possessed the unique carbon skeleton conjugated of a fla...

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Bibliographic Details
Published in:Helvetica chimica acta 2016-07, Vol.99 (7), p.499-505
Main Authors: Jia, Bei-Xi, Jia, Ao, Li, Chao-Jie, Zhao, Hui-Qin, Ren, Feng-Xiao, Liu, Hong-Min, Wang, Qiang
Format: Article
Language:English
Subjects:
Baeckea frutescens
Baeckeins J and K
C-Methylated biflavonoid
Cytoprotective activity
Myrtaceae
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Summary:Baeckea frutescens is an aromatic shrub used as ornamentals and as food flavor spices in the southern part of P. R. China. Two novel C‐methylated biflavonoids named baeckeins J (1) and K (2) were isolated from the roots of B. frutescens, which possessed the unique carbon skeleton conjugated of a flavonol and one isoflavanonol molecule via the linkages of C(2)–C(8*) and C(3)–O–C(7*). The structures of compounds 1 and 2 were elucidated by analysis of 1D‐ and 2D‐NMR, and HR‐ESI‐MS spectral data, and the absolute configuration for chiral C‐atoms C(2) and C(3) were assigned by CD spectrometry combined with quantum chemical calculations. In the bioassay, baeckeins J and K exhibited strong cytoprotective effects on H2O2‐induced oxidative cell death in PC12 cells.
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.201600013