Basic Ionic Liquid as Catalyst and Reaction Media for the One-pot Three-component Regioselective Synthesis of Various Thiazol-2-imine Derivatives

Thiazol‐2‐imine derivatives were synthesized in an easy and efficient route from the regioselective one‐pot three‐component reaction of aryl amine, alkylisothiocyanate, and various α‐haloketones in [omim][OH] basic ionic liquid. Recyclable reaction media, catalyst free, and short reaction times are...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2016-07, Vol.53 (4), p.1009-1016
Main Authors: Shiran, Jafar Abbasi, Yahyazadeh, Asieh, Yamin, Bohari M., Mamaghani, Manouchehr, Albadi, Jalal
Format: Article
Language:English
Subjects:
Ions
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Summary:Thiazol‐2‐imine derivatives were synthesized in an easy and efficient route from the regioselective one‐pot three‐component reaction of aryl amine, alkylisothiocyanate, and various α‐haloketones in [omim][OH] basic ionic liquid. Recyclable reaction media, catalyst free, and short reaction times are the main advantages of this protocol. This method produces the products at room temperature in excellent yields (68–96%). Furthermore, the target compound 6b was determined by X‐ray crystallographic analysis.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.2406