Anti-inflammatory effect of a resveratrol derivative 3,4,5-trimethoxy-4[variant prime],5[variant prime]-dihydroxy-trans-stilbene (WL-09-5) via ROS-mediated NF-[kappa]B pathway

• Published in: Journal of asian natural products research 2016-10, Vol.18 (10), p.1004
• Main Authors: Ma, Pei, Ding, Ya-Si, Xuan, Ling-Ling, Wang, Lin, Shi, Ji, Bai, Jin-Ye, Lin, Ming-Bao, Zheng, Wen-Sheng, Hou, Qi
• Format: Article
• Language: English
• Subjects: Edema; Rodents
• ISSN: 1028-6020; 1477-2213
• DOI: 10.1080/10286020.2016.1181622

Inflammation derived from macrophages activation leads to various diseases. Synthetic modifications of resveratrol have been shown to have better anti-inflammatory activities. In this study, croton oil-induced mouse ear edema and lipopolysaccharides (LPS)-stimulated RAW264.7 macrophages were used to evaluate the anti-inflammatory effects of WL-09-5, a derivative of resveratrol. Furthermore, the activation of NF-κB was determined. Results showed that WL-09-5 significantly reduced the croton oil-induced ear edema, scavenged NO and ROS production, and reduced the levels of TNF-α, IL-6, and IL-1[beta]. Furthermore, WL-09-5 may significantly inhibit the translocation of NF-κB in macrophage cells stimulated by LPS in a dose-dependent manner, which is a potent mechanism of its anti-inflammatory effects. In conclusion, WL-09-5 is an underlying candidate for inflammatory diseases that need further investigations.