Effect of picrotoxin-induced seizures on lipid composition of cortical tissue homogenate and its nuclear fraction in rats

The content of lipids in rat cortical tissue homogenate and fraction of neuronal nuclei was determined under normal conditions and after picrotoxin-induced seizures. Changes in lipid composition of homogenate and nuclear fraction differed considerably. In homogenate, the content of sphingomyelin, ly...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2000-09, Vol.130 (9), p.864
Main Authors: Kulagina, T P, Kolomiitseva, I K, Arkhipov, V I
Format: Article
Language:English
Subjects:
Animals
Cell Nucleus - metabolism
Cerebral Cortex - metabolism
Cerebral Cortex - physiopathology
Convulsants
Fatty acids
Fractions
Lipid Metabolism
Male
Picrotoxin
Rats
Rats, Wistar
Seizures - chemically induced
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Summary:The content of lipids in rat cortical tissue homogenate and fraction of neuronal nuclei was determined under normal conditions and after picrotoxin-induced seizures. Changes in lipid composition of homogenate and nuclear fraction differed considerably. In homogenate, the content of sphingomyelin, lysophosphatidylcholine, and total phospholipids increased, while the content of free fatty acid remained unchanged; in the nuclear fraction the total phospholipid content decreased, while the concentration of free fatty acids increased.
ISSN:0007-4888
1573-8221
DOI:10.1023/A:1015362128097