Antibiothérapie du sujet âgé : On peut toujours mieux faire

Antimicrobials are among the most prescribed drugs and their prescription increases with age, due to frailty and accrued risk factors for acquiring infections. Antimicrobial prescription in elderly patients must not only account for the risk of toxicity due to drug overexposure, but also of treatmen...

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Bibliographic Details
Published in:Canadian journal on aging 2016-09, Vol.35 (3), p.385-392
Main Authors: Tolsma, Violaine, Gaillat, Jacques, Pagani, Leonardo
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aging
Aging - metabolism
Anti-Infective Agents - pharmacokinetics
Anti-Infective Agents - pharmacology
Anti-Infective Agents - therapeutic use
Antibiotics
Comorbidity
Cytochrome
Drug therapy
Enzymes
Humans
Infection - drug therapy
Microbiology
Older people
Patients
Polypharmacy
Prescription drugs
Resistance
Risk factors
Studies
Citations: Items that this one cites
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Summary:Antimicrobials are among the most prescribed drugs and their prescription increases with age, due to frailty and accrued risk factors for acquiring infections. Antimicrobial prescription in elderly patients must not only account for the risk of toxicity due to drug overexposure, but also of treatment failure or promotion of antimicrobial resistance due to under-dosage. This paper reviews the main antimicrobial, pharmacokinetic and pharmacodynamic variations induced by aging, comorbidities and polypharmacy, and how to take them into account to optimize antimicrobial prescription in elders.
ISSN:0714-9808
1710-1107
DOI:10.1017/S0714980816000350