Small-quantity, lipid-based nutrient supplements provided to women during pregnancy and 6 mo postpartum and to their infants from 6 mo of age increase the mean attained length of 18-mo-old children in semi-urban Ghana: a randomized controlled trial

Childhood stunting usually begins in utero and continues after birth; therefore, its reduction must involve actions across different stages of early life. We evaluated the efficacy of small-quantity, lipid-based nutrient supplements (SQ-LNSs) provided during pregnancy, lactation, and infancy on atta...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of clinical nutrition 2016-09, Vol.104 (3), p.797-808
Main Authors: Adu-Afarwuah, Seth, Lartey, Anna, Okronipa, Harriet, Ashorn, Per, Peerson, Janet M, Arimond, Mary, Ashorn, Ulla, Zeilani, Mamane, Vosti, Stephen, Dewey, Kathryn G
Format: Article
Language:English
Subjects:
Adult
Body Height - ethnology
Child Development
Children & youth
Clinical trials
Dietary Fats - adverse effects
Dietary Fats - therapeutic use
Dietary supplements
Dietary Supplements - adverse effects
Double-Blind Method
Female
Fetal Development
Fetal Growth Retardation - epidemiology
Fetal Growth Retardation - ethnology
Fetal Growth Retardation - physiopathology
Fetal Growth Retardation - prevention & control
Ghana - epidemiology
Growth Disorders - epidemiology
Growth Disorders - ethnology
Growth Disorders - etiology
Growth Disorders - prevention & control
Humans
Infant Nutrition Disorders - epidemiology
Infant Nutrition Disorders - ethnology
Infant Nutrition Disorders - physiopathology
Infant Nutrition Disorders - prevention & control
Infant Nutritional Physiological Phenomena - ethnology
Infant, Newborn
Lactation - ethnology
Lipids
Male
Maternal Nutritional Physiological Phenomena - ethnology
Micronutrients - adverse effects
Micronutrients - therapeutic use
Postpartum period
Pregnancy
Pregnancy Trimester, First
Prevalence
Risk
Suburban Health - ethnology
Women
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Childhood stunting usually begins in utero and continues after birth; therefore, its reduction must involve actions across different stages of early life. We evaluated the efficacy of small-quantity, lipid-based nutrient supplements (SQ-LNSs) provided during pregnancy, lactation, and infancy on attained size by 18 mo of age. In this partially double-blind, individually randomized trial, 1320 women at ≤20 wk of gestation received standard iron and folic acid (IFA group), multiple micronutrients (MMN group), or SQ-LNS (LNS group) daily until delivery, and then placebo, MMNs, or SQ-LNS, respectively, for 6 mo postpartum; infants in the LNS group received SQ-LNS formulated for infants from 6 to 18 mo of age (endline). The primary outcome was child length by 18 mo of age. At endline, data were available for 85% of 1228 infants enrolled; overall mean length and length-for-age z score (LAZ) were 79.3 cm and -0.83, respectively, and 12% of the children were stunted (LAZ
ISSN:0002-9165
1938-3207
DOI:10.3945/ajcn.116.134692