Aloeverasides A and B: Two Bioactive C-Glucosyl Chromones from Aloe vera Resin

Two new C‐glucosyl chromones named aloeverasides A (1) and B (2) were isolated from the resin of Aloe vera (L.) Burm.f. The structures of the two new natural products were elucidated based on 1D‐ (1H‐ and 13C‐NMR) and 2D‐NMR (COSY, HSQC, and HMBC) spectroscopic techniques and mass spectrometry (ESI‐...

Full description

Saved in:
Bibliographic Details
Published in:Helvetica chimica acta 2016-09, Vol.99 (9), p.687-690
Main Authors: Rehman, Najeeb Ur, Hussain, Hidayat, Khiat, Mohammed, Al-Riyami, Samia Ahmed, Csuk, René, Khan, Husain Yar, Abbas, Ghulam, Al-Thani, Ghanim Salim, Green, Ivan R., Al-Harrasi, Ahmed
Format: Article
Language:English
Subjects:
Aloe vera (L.) Burm.f
Chromones
Natural products
Structure elucidation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Two new C‐glucosyl chromones named aloeverasides A (1) and B (2) were isolated from the resin of Aloe vera (L.) Burm.f. The structures of the two new natural products were elucidated based on 1D‐ (1H‐ and 13C‐NMR) and 2D‐NMR (COSY, HSQC, and HMBC) spectroscopic techniques and mass spectrometry (ESI‐MS). Aloeverasides A (1) and B (2) were evaluated for their anticancer activity, and both induced a 76.4 and 70.5% growth inhibition of the breast cancer cell line (MDA‐MB‐231) at a concentration of 100 μm. Both compounds were also evaluated for their 1,1‐diphenyl‐2‐picryl‐hydrazyl antioxidant, urease enzyme, and α‐glucosidase enzyme inhibition activities. Aloeverasides A (1) and B (2) displayed good urease enzyme inhibition activities (62 and 55%, resp.), as well as antioxidant activity in which aloeveraside A (1) had a value of 60% inhibition, while aloeveraside B (2) demonstrated a more potent antioxidant activity with 80% inhibition.
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.201600126