Antidepressants for schizophrenia have benefits, but effect sizes small

A review and meta‐analysis encompassing 82 randomized controlled trials has found that adding an antidepressant to antipsychotic treatment for schizophrenia generated benefits on a number of symptoms and quality‐of‐life indicators, although effect sizes were small. The analysis also found that adjun...

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Bibliographic Details
Published in:Psychopharmacology update 2016-10, Vol.27 (10), p.1-7
Main Authors: Helfer, B, Samara, M.T, Huhn, M
Format: Article
Language:English
Subjects:
Antidepressants
Antipsychotic agents
Depression (Mood disorder)
Drug therapy
Psychopharmacology
Schizophrenia
Tricyclic antidepressants
Online Access:Get full text
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Summary:A review and meta‐analysis encompassing 82 randomized controlled trials has found that adding an antidepressant to antipsychotic treatment for schizophrenia generated benefits on a number of symptoms and quality‐of‐life indicators, although effect sizes were small. The analysis also found that adjunctive antidepressants did not exacerbate psychosis or adverse events. Results were published online June 10 in the American Journal of Psychiatry.
ISSN:1068-5308
1556-7532
DOI:10.1002/pu.30175