Incidence of cardiovascular events in HIV-positive patients compared to general population over the last decade: a population-based study from 2000 to 2012

Cardiovascular diseases are currently a main cause of death among people living with HIV. This population-based study aimed to investigate the incidence of cardiovascular events (CVEs) in HIV-positive people and factors associated with CVEs. We performed a retrospective cohort study of the HIV-infec...

Full description

Saved in:
Bibliographic Details
Published in:AIDS care 2016-12, Vol.28 (12), p.1551-1558
Main Authors: Quiros-Roldan, Eugenia, Raffetti, Elena, Focà, Emanuele, Brianese, Nigritella, Ferraresi, Alice, Paraninfo, Giuseppe, Pezzoli, Maria Chiara, Bonito, Andrea, Magoni, Michele, Scarcella, Carmelo, Castelli, Francesco
Format: Article
Language:English
Subjects:
Adult
Age Factors
AIDS/HIV
Antiretroviral drugs
Blood
Cardiovascular disease
Cardiovascular diseases
Cholesterol
Cholesterol - blood
Cohort analysis
Competing risks models
Death & dying
Diabetes
Diabetes mellitus
Diabetes Mellitus - epidemiology
Female
Females
Gender
Gender aspects
Gender differences
Health risk assessment
Health risks
Heart attacks
Heart diseases
HIV
HIV Seropositivity - epidemiology
Human immunodeficiency virus
Humans
Incidence
Italy - epidemiology
Lentivirus
Male
Middle Aged
Myocardial infarction
Myocardial Infarction - epidemiology
Patients
Population
Population studies
population-based
Positive life events
Regression analysis
Retrospective Studies
Retroviridae
Risk analysis
Risk assessment
Risk Factors
Sex differences
Sex Factors
Stroke
Stroke - epidemiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cardiovascular diseases are currently a main cause of death among people living with HIV. This population-based study aimed to investigate the incidence of cardiovascular events (CVEs) in HIV-positive people and factors associated with CVEs. We performed a retrospective cohort study of the HIV-infected patients residing in the Local Health Authority of Brescia, northern Italy, from 2000 to 2012. Incidence of CVEs events in HIV-positive patients was compared with that expected in general population living in the same area, computing standardized incidence ratios (SIRs). CVEs-associated risk factors were assessed using Cox regression analysis and competing risk model of death. About 3766 HIV-infected patients were included in the study. Over the 12-year-period, we recorded 134 CVEs: 83 (61.9%) acute myocardial infarctions (CVE type-1), and 51 (38.1%) strokes (CVE type-2). A twofold increased risk (SIR = 2.02) of CVEs was found in HIV-infected patients compared to the general population. Notably, within male patients: for CVE type-1, SIR = 1.89, for CVE type-2 SIR = 2.25; within female patients: for CVE type-1, SIR = 2.91, for CVE type-2 SIR = 2.07. Age >45 years, male gender, diabetes, and total blood cholesterol >200 mg/dl were significantly associated with CVEs incidence (for all, p 
ISSN:0954-0121
1360-0451
DOI:10.1080/09540121.2016.1198750