GW27-e1035 The effect of methylation of ATRAP gene on left ventricular hypertrophy in spontaneously hypertensive rats treated early with losartan

Objectives To investigate long-term influence of early treatment of spontaneously hypertensive rats (SHR) with losartan (Los) on blood pressure, left ventricular hypertrophy and expression of angiotensin type 1 receptor-associated protein (ATRAP) in myocardium, and to explore the role of DNA methyla...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American College of Cardiology 2016-10, Vol.68 (16), p.C37-C38
Main Authors: Tingjun, Wang, Lian, Guili, Xu, Changsheng, Lin, Xu, Chen, Wanru, Xie, Liangdi
Format: Article
Language:English
Subjects:
Cardiology
Cardiovascular
Deoxyribonucleic acid
DNA
DNA methylation
Genes
Hypertension
Internal Medicine
Protein synthesis
Proteins
Rodents
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives To investigate long-term influence of early treatment of spontaneously hypertensive rats (SHR) with losartan (Los) on blood pressure, left ventricular hypertrophy and expression of angiotensin type 1 receptor-associated protein (ATRAP) in myocardium, and to explore the role of DNA methylation in the long-term effect of Los.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2016.07.139