The association of clinical findings and exposure profiles with melamine associated nephrolithiasis

Background: Little is known about the exposure profiles of melamine in children. We evaluated the association of clinical findings, exposure patterns and biomarkers with nephrolithiasis in children with potential exposure to melamine. Methods: A case-control study was conducted in children aged 0–16...

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Bibliographic Details
Published in:Archives of disease in childhood 2009-11, Vol.94 (11), p.883-887
Main Authors: Wang, I J, Wu, Y N, Wu, W C, Leonardi, G, Sung, Y J, Lin, T J, Wang, C L, Kuo, C F, Wu, K Y, Cheng, W C, Chan, C C, Chen, P C, Lin, S-L
Format: Article
Language:English
Subjects:
Adolescent
Baby foods
Biological and medical sciences
Biological markers
Biomarkers
Biomarkers - urine
Case-Control Studies
Child
Child Health
Child, Preschool
Children & youth
China
Control Groups
Creatinine
Dairy products
Dairy Products - analysis
Detection limits
Diseases
Exposure
Female
Food Contamination
Food contamination & poisoning
Food safety
Food Standards
Gender
General aspects
Health aspects
Humans
Identification and classification
Infant
Infant Formula
Infant, Newborn
Infants (Newborn)
Kidney stones
Laboratories
Male
Medical sciences
Melamine
Milk
Miscellaneous
Neonatal diseases
Nephrolithiasis - chemically induced
Nephrolithiasis - diagnostic imaging
Nephrolithiasis - epidemiology
Nephrology. Urinary tract diseases
Outdoor air quality
Prevention and actions
Public health. Hygiene
Public health. Hygiene-occupational medicine
Risk Factors
Statistical Analysis
Taiwan - epidemiology
Time Factors
Triazines - adverse effects
Triazines - urine
Ultrasonic imaging
Ultrasonography
Urinary lithiasis
Urine
Young Children
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Description
Summary:Background: Little is known about the exposure profiles of melamine in children. We evaluated the association of clinical findings, exposure patterns and biomarkers with nephrolithiasis in children with potential exposure to melamine. Methods: A case-control study was conducted in children aged 0–16 years with potential exposure to contaminated dairy products. Cases were defined as nephrolithiasis detected by renal ultrasonography. On the basis of different brands of contaminated dairy products consumed, subjects were classified into high exposure, low exposure and control groups with estimated melamine exposure levels of higher than 2.5 ppm, 0.05–2.5 ppm and lower than detection limits
ISSN:0003-9888
1468-2044
DOI:10.1136/adc.2009.163477