Carry on doctor

We report the case of a 13-year-old girl with tuberculosis who developed persistent symptomatic thrombocytopenia whilst being treated with rifampicin and isoniazid. There was widespread agreement that rifampicin was the likely cause of the thrombocytopenia. After discussion with the family we electe...

Full description

Saved in:
Bibliographic Details
Published in:Archives of disease in childhood 2009-09, Vol.94 (9), p.734-735
Main Authors: Nair, S, Carroll, W D
Format: Article
Language:English
Subjects:
Adolescent
Antibiotics, Antitubercular - adverse effects
Antibiotics, Antitubercular - therapeutic use
Biological and medical sciences
Blood platelets
Case studies
Complications and side effects
Demographic aspects
Diagnosis
Drug dosages
Drug therapy
Families & family life
Female
General aspects
Grade 2
Health participants
Hematology
Humans
Immunoglobulins
Isoniazid
Isoniazid - therapeutic use
Literature Reviews
Lung - diagnostic imaging
Medical sciences
Medical Services
Miscellaneous
Narcotics
Prevention and actions
Public health. Hygiene
Public health. Hygiene-occupational medicine
Radiography
Rifampin
Rifampin - adverse effects
Rifampin - therapeutic use
Thrombocytopenia
Thrombocytopenia - chemically induced
Thrombocytopenia - diagnostic imaging
Treatment Outcome
Tuberculosis
Tuberculosis, Pulmonary - diagnostic imaging
Tuberculosis, Pulmonary - drug therapy
Visual Acuity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We report the case of a 13-year-old girl with tuberculosis who developed persistent symptomatic thrombocytopenia whilst being treated with rifampicin and isoniazid. There was widespread agreement that rifampicin was the likely cause of the thrombocytopenia. After discussion with the family we elected to continue treatment as we believed that the potential benefits of continuing treatment outweighed the risks of thrombocytopenia. Despite continued treatment the platelet count returned to normal after a few weeks. We found that thrombocytopaenia may be transient even when therapy is continued and would recommend a watchful waiting strategy to others faced with a similar clinical dilemma.
ISSN:0003-9888
1468-2044
DOI:10.1136/adc.2008.156299