Loading…

Carry on doctor

We report the case of a 13-year-old girl with tuberculosis who developed persistent symptomatic thrombocytopenia whilst being treated with rifampicin and isoniazid. There was widespread agreement that rifampicin was the likely cause of the thrombocytopenia. After discussion with the family we electe...

Full description

Saved in:
Bibliographic Details
Published in:Archives of disease in childhood 2009-09, Vol.94 (9), p.734-735
Main Authors: Nair, S, Carroll, W D
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-b502t-c6efcd79301345510e8f9560b72d9bbe66c6790fa5f8f29c93383760e74c0ad63
cites cdi_FETCH-LOGICAL-b502t-c6efcd79301345510e8f9560b72d9bbe66c6790fa5f8f29c93383760e74c0ad63
container_end_page 735
container_issue 9
container_start_page 734
container_title Archives of disease in childhood
container_volume 94
creator Nair, S
Carroll, W D
description We report the case of a 13-year-old girl with tuberculosis who developed persistent symptomatic thrombocytopenia whilst being treated with rifampicin and isoniazid. There was widespread agreement that rifampicin was the likely cause of the thrombocytopenia. After discussion with the family we elected to continue treatment as we believed that the potential benefits of continuing treatment outweighed the risks of thrombocytopenia. Despite continued treatment the platelet count returned to normal after a few weeks. We found that thrombocytopaenia may be transient even when therapy is continued and would recommend a watchful waiting strategy to others faced with a similar clinical dilemma.
doi_str_mv 10.1136/adc.2008.156299
format article
fullrecord <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_1828678884</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A211085410</galeid><sourcerecordid>A211085410</sourcerecordid><originalsourceid>FETCH-LOGICAL-b502t-c6efcd79301345510e8f9560b72d9bbe66c6790fa5f8f29c93383760e74c0ad63</originalsourceid><addsrcrecordid>eNqNkM9LHDEUgEOp1K1Kj72VBelFmN2X3y9HGWwVFj24ireQyWRkt7Mz22QW9L83Mose9fQO70vex0fITwozSrmau9rPGADOqFTMmC9kQoXCgoEQX8kEAHhhEPGQfE9pDUAZIv9GDqnRAILhhPwoXYzP076b1r0f-nhMDhrXpnCyn0fk7s_FsrwsFjd_r8rzRVFJYEPhVWh8rQ0HyoWUFAI2RiqoNKtNVQWlvNIGGicbbJjxhnPkWkHQwoOrFT8ip-O_29j_34U02HW_i10-aSkyVDpbi0wVI_Xo2mBXne-7ITwNvm_b8BhsNipv7DmjIt9GrT_NU0ApKGR-PvI-9inF0NhtXG1cfLYU7GtgmwPb18B2DJxf_Np776pNqN_5fdEM_N4DLnnXNtF1fpXeOEaRgxTqXXWVsuLb3sV_Vmmupb2-Ly3ePiyWhl_b28yfjXy1WX9o-QIMw5mg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1828678884</pqid></control><display><type>article</type><title>Carry on doctor</title><source>Social Science Premium Collection (Proquest) (PQ_SDU_P3)</source><source>Education Collection</source><creator>Nair, S ; Carroll, W D</creator><creatorcontrib>Nair, S ; Carroll, W D</creatorcontrib><description>We report the case of a 13-year-old girl with tuberculosis who developed persistent symptomatic thrombocytopenia whilst being treated with rifampicin and isoniazid. There was widespread agreement that rifampicin was the likely cause of the thrombocytopenia. After discussion with the family we elected to continue treatment as we believed that the potential benefits of continuing treatment outweighed the risks of thrombocytopenia. Despite continued treatment the platelet count returned to normal after a few weeks. We found that thrombocytopaenia may be transient even when therapy is continued and would recommend a watchful waiting strategy to others faced with a similar clinical dilemma.</description><identifier>ISSN: 0003-9888</identifier><identifier>EISSN: 1468-2044</identifier><identifier>DOI: 10.1136/adc.2008.156299</identifier><identifier>PMID: 19700428</identifier><identifier>CODEN: ADCHAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Adolescent ; Antibiotics, Antitubercular - adverse effects ; Antibiotics, Antitubercular - therapeutic use ; Biological and medical sciences ; Blood platelets ; Case studies ; Complications and side effects ; Demographic aspects ; Diagnosis ; Drug dosages ; Drug therapy ; Families &amp; family life ; Female ; General aspects ; Grade 2 ; Health participants ; Hematology ; Humans ; Immunoglobulins ; Isoniazid ; Isoniazid - therapeutic use ; Literature Reviews ; Lung - diagnostic imaging ; Medical sciences ; Medical Services ; Miscellaneous ; Narcotics ; Prevention and actions ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Radiography ; Rifampin ; Rifampin - adverse effects ; Rifampin - therapeutic use ; Thrombocytopenia ; Thrombocytopenia - chemically induced ; Thrombocytopenia - diagnostic imaging ; Treatment Outcome ; Tuberculosis ; Tuberculosis, Pulmonary - diagnostic imaging ; Tuberculosis, Pulmonary - drug therapy ; Visual Acuity</subject><ispartof>Archives of disease in childhood, 2009-09, Vol.94 (9), p.734-735</ispartof><rights>BMJ Publishing Group Ltdand Royal College of Paediatrics and Child Health.</rights><rights>2009 INIST-CNRS</rights><rights>Copyright: 2009 BMJ Publishing Group Ltdand Royal College of Paediatrics and Child Health.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b502t-c6efcd79301345510e8f9560b72d9bbe66c6790fa5f8f29c93383760e74c0ad63</citedby><cites>FETCH-LOGICAL-b502t-c6efcd79301345510e8f9560b72d9bbe66c6790fa5f8f29c93383760e74c0ad63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1828678884/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1828678884?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,21359,21375,27903,27904,33590,33856,43712,43859,73967,74143</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=21830546$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19700428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nair, S</creatorcontrib><creatorcontrib>Carroll, W D</creatorcontrib><title>Carry on doctor</title><title>Archives of disease in childhood</title><addtitle>Arch Dis Child</addtitle><description>We report the case of a 13-year-old girl with tuberculosis who developed persistent symptomatic thrombocytopenia whilst being treated with rifampicin and isoniazid. There was widespread agreement that rifampicin was the likely cause of the thrombocytopenia. After discussion with the family we elected to continue treatment as we believed that the potential benefits of continuing treatment outweighed the risks of thrombocytopenia. Despite continued treatment the platelet count returned to normal after a few weeks. We found that thrombocytopaenia may be transient even when therapy is continued and would recommend a watchful waiting strategy to others faced with a similar clinical dilemma.</description><subject>Adolescent</subject><subject>Antibiotics, Antitubercular - adverse effects</subject><subject>Antibiotics, Antitubercular - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Blood platelets</subject><subject>Case studies</subject><subject>Complications and side effects</subject><subject>Demographic aspects</subject><subject>Diagnosis</subject><subject>Drug dosages</subject><subject>Drug therapy</subject><subject>Families &amp; family life</subject><subject>Female</subject><subject>General aspects</subject><subject>Grade 2</subject><subject>Health participants</subject><subject>Hematology</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Isoniazid</subject><subject>Isoniazid - therapeutic use</subject><subject>Literature Reviews</subject><subject>Lung - diagnostic imaging</subject><subject>Medical sciences</subject><subject>Medical Services</subject><subject>Miscellaneous</subject><subject>Narcotics</subject><subject>Prevention and actions</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Radiography</subject><subject>Rifampin</subject><subject>Rifampin - adverse effects</subject><subject>Rifampin - therapeutic use</subject><subject>Thrombocytopenia</subject><subject>Thrombocytopenia - chemically induced</subject><subject>Thrombocytopenia - diagnostic imaging</subject><subject>Treatment Outcome</subject><subject>Tuberculosis</subject><subject>Tuberculosis, Pulmonary - diagnostic imaging</subject><subject>Tuberculosis, Pulmonary - drug therapy</subject><subject>Visual Acuity</subject><issn>0003-9888</issn><issn>1468-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>ALSLI</sourceid><sourceid>CJNVE</sourceid><sourceid>M0P</sourceid><recordid>eNqNkM9LHDEUgEOp1K1Kj72VBelFmN2X3y9HGWwVFj24ireQyWRkt7Mz22QW9L83Mose9fQO70vex0fITwozSrmau9rPGADOqFTMmC9kQoXCgoEQX8kEAHhhEPGQfE9pDUAZIv9GDqnRAILhhPwoXYzP076b1r0f-nhMDhrXpnCyn0fk7s_FsrwsFjd_r8rzRVFJYEPhVWh8rQ0HyoWUFAI2RiqoNKtNVQWlvNIGGicbbJjxhnPkWkHQwoOrFT8ip-O_29j_34U02HW_i10-aSkyVDpbi0wVI_Xo2mBXne-7ITwNvm_b8BhsNipv7DmjIt9GrT_NU0ApKGR-PvI-9inF0NhtXG1cfLYU7GtgmwPb18B2DJxf_Np776pNqN_5fdEM_N4DLnnXNtF1fpXeOEaRgxTqXXWVsuLb3sV_Vmmupb2-Ly3ePiyWhl_b28yfjXy1WX9o-QIMw5mg</recordid><startdate>20090901</startdate><enddate>20090901</enddate><creator>Nair, S</creator><creator>Carroll, W D</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ Publishing Group</general><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8A4</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope></search><sort><creationdate>20090901</creationdate><title>Carry on doctor</title><author>Nair, S ; Carroll, W D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b502t-c6efcd79301345510e8f9560b72d9bbe66c6790fa5f8f29c93383760e74c0ad63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Antibiotics, Antitubercular - adverse effects</topic><topic>Antibiotics, Antitubercular - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Blood platelets</topic><topic>Case studies</topic><topic>Complications and side effects</topic><topic>Demographic aspects</topic><topic>Diagnosis</topic><topic>Drug dosages</topic><topic>Drug therapy</topic><topic>Families &amp; family life</topic><topic>Female</topic><topic>General aspects</topic><topic>Grade 2</topic><topic>Health participants</topic><topic>Hematology</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Isoniazid</topic><topic>Isoniazid - therapeutic use</topic><topic>Literature Reviews</topic><topic>Lung - diagnostic imaging</topic><topic>Medical sciences</topic><topic>Medical Services</topic><topic>Miscellaneous</topic><topic>Narcotics</topic><topic>Prevention and actions</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Radiography</topic><topic>Rifampin</topic><topic>Rifampin - adverse effects</topic><topic>Rifampin - therapeutic use</topic><topic>Thrombocytopenia</topic><topic>Thrombocytopenia - chemically induced</topic><topic>Thrombocytopenia - diagnostic imaging</topic><topic>Treatment Outcome</topic><topic>Tuberculosis</topic><topic>Tuberculosis, Pulmonary - diagnostic imaging</topic><topic>Tuberculosis, Pulmonary - drug therapy</topic><topic>Visual Acuity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nair, S</creatorcontrib><creatorcontrib>Carroll, W D</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection【Remote access available】</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Education Periodicals</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Social Science Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Education Database</collection><collection>Consumer Health Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>Archives of disease in childhood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nair, S</au><au>Carroll, W D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carry on doctor</atitle><jtitle>Archives of disease in childhood</jtitle><addtitle>Arch Dis Child</addtitle><date>2009-09-01</date><risdate>2009</risdate><volume>94</volume><issue>9</issue><spage>734</spage><epage>735</epage><pages>734-735</pages><issn>0003-9888</issn><eissn>1468-2044</eissn><coden>ADCHAK</coden><abstract>We report the case of a 13-year-old girl with tuberculosis who developed persistent symptomatic thrombocytopenia whilst being treated with rifampicin and isoniazid. There was widespread agreement that rifampicin was the likely cause of the thrombocytopenia. After discussion with the family we elected to continue treatment as we believed that the potential benefits of continuing treatment outweighed the risks of thrombocytopenia. Despite continued treatment the platelet count returned to normal after a few weeks. We found that thrombocytopaenia may be transient even when therapy is continued and would recommend a watchful waiting strategy to others faced with a similar clinical dilemma.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>19700428</pmid><doi>10.1136/adc.2008.156299</doi><tpages>2</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0003-9888
ispartof Archives of disease in childhood, 2009-09, Vol.94 (9), p.734-735
issn 0003-9888
1468-2044
language eng
recordid cdi_proquest_journals_1828678884
source Social Science Premium Collection (Proquest) (PQ_SDU_P3); Education Collection
subjects Adolescent
Antibiotics, Antitubercular - adverse effects
Antibiotics, Antitubercular - therapeutic use
Biological and medical sciences
Blood platelets
Case studies
Complications and side effects
Demographic aspects
Diagnosis
Drug dosages
Drug therapy
Families & family life
Female
General aspects
Grade 2
Health participants
Hematology
Humans
Immunoglobulins
Isoniazid
Isoniazid - therapeutic use
Literature Reviews
Lung - diagnostic imaging
Medical sciences
Medical Services
Miscellaneous
Narcotics
Prevention and actions
Public health. Hygiene
Public health. Hygiene-occupational medicine
Radiography
Rifampin
Rifampin - adverse effects
Rifampin - therapeutic use
Thrombocytopenia
Thrombocytopenia - chemically induced
Thrombocytopenia - diagnostic imaging
Treatment Outcome
Tuberculosis
Tuberculosis, Pulmonary - diagnostic imaging
Tuberculosis, Pulmonary - drug therapy
Visual Acuity
title Carry on doctor
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T22%3A13%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Carry%20on%20doctor&rft.jtitle=Archives%20of%20disease%20in%20childhood&rft.au=Nair,%20S&rft.date=2009-09-01&rft.volume=94&rft.issue=9&rft.spage=734&rft.epage=735&rft.pages=734-735&rft.issn=0003-9888&rft.eissn=1468-2044&rft.coden=ADCHAK&rft_id=info:doi/10.1136/adc.2008.156299&rft_dat=%3Cgale_proqu%3EA211085410%3C/gale_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-b502t-c6efcd79301345510e8f9560b72d9bbe66c6790fa5f8f29c93383760e74c0ad63%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1828678884&rft_id=info:pmid/19700428&rft_galeid=A211085410&rfr_iscdi=true