Paediatric adverse drug event clinic

• Published in: Archives of disease in childhood 2012-05, Vol.97 (Suppl 1), p.A39-A39
• Main Authors: Beesley, OR, Thompson, JP, Powell, R, Spear, E, Tuthill, DP
• Format: Article
• Language: English
• Subjects: Allergies; Allergy; Antimicrobial agents; Immunology; Narcotics; Side effects
• ISSN: 0003-9888; 1468-2044
• DOI: 10.1136/archdischild-2012-301885.97

Introduction Of paediatric admissions to hospital, up to 1.8% are a consequence of Adverse Drug Reactions (ADR); a proportion are allergic reactions. Misdiagnosis of drug allergy is important not only for the patient, but also because unevaluated reactions can lead to less effective and more expensive drugs being prescribed. Aim To describe the suspected causative drugs, clinical features, investigations, diagnosis and advice given to patients presenting to the Paediatric Adverse Drug Event Clinic. Methods A retrospective clinic note review was undertaken of all patients presenting to the Adverse Drug Event Clinic with a suspected drug allergy between 2005 and 2010. Children were identified though the electronic letter copies of one consultant. Results Table 1: 66 children (mean age 9.7 years) attended. The suspected drugs were: Antimicrobials (26), Local anaesthetics (17),General anaesthetics (16), Other (7). Rash (31), swelling (28) and urticaria (13) were the most common clinical presentations (table 1). Abstract G47(P) Table 1 Investigations Investigation Number of cases Number of negative results Skin prick testing 60 49 Specific serum IgE 10 10 Intradermal testing 6 5 Direct provocation test 5 5 Table 2: A diagnosis of drug allergy was given in 14 children (21%); all were advised to avoid the drug. Abstract G47(P) Table 2 Advice Advice Total Reassurance 38 Avoid 14 Pragmatically avoid 11 Other 3 Conclusions Medication and Anaesthetic charts are vital in the assessment of potential drug allergy. Investigation to multiple drugs is generally possible in one clinic visit. Around a quarter had a “confirmed” drug allergy. A Drug Challenge (Direct provocation test) was infrequently required to manage the children. These results are in concordance with the British Society for Allergy and Clinical Immunology guidelines, which recommends a drug challenge should only be considered after other investigations have been exhausted and the diagnosis is still unclear.