1653 Acute Intoxications with drug Substances in Children - A Clinical Epidemiological Study

• Published in: Archives of disease in childhood 2012-10, Vol.97 (Suppl 2), p.A467-A468
• Main Authors: Singer, CE, Stancu, P, Cosoveanu, SC, Botu, A, Costache, S, Cristea, C
• Format: Article
• Language: English
• Subjects: Antibiotics; Antipsychotics; Narcotics; Social Environment
• ISSN: 0003-9888; 1468-2044
• DOI: 10.1136/archdischild-2012-302724.1653

Objectives Incidence of acute drug intoxications (ADI) within general pathology and various parameters (sex, social environment, age group, etiologic spectrum, clinical form, average period of hospitalization). Material and Method A retrospective statistic study of ADI in children aged 0–16 years, admitted to 2nd Pediatric Clinic, Emergency County Hospital Craiova, over a period of 6 years (01.01.2006–31.12.2011). Results Of the total number of 14427 admitted children, aged 0–16 years, 645 presented acute intoxications with various etiologies, among which 252 had ADI; intoxication type: accidental in 154 (61.1%), voluntary in 98 (38.9%). Accidental ADI: sex M/F=54/100, social environment U/R=93/61, age group (years): 0–1/1–3/3–6/6–10= 27/68/33/26. Voluntary ADI: M/F=23/75, U/R=59/39, age (years): 6–10/ 10–14/14–16= 7/37/54. Etiologic spectrum in the studied group: AINS/antialgics in 39 (15.5%), methoclopramid 29 (11.5%), anti-epileptics 24 (9.5%), tranquilizers/sedatives 15 (5.9%), neuroleptics 9 (3.6%), para-sympathicolitics 8 (3.2%), antibiotics/antiparasitary 17 (6.7%), drugs with cardio-vascular effect 8 (3.2%), drug combinations 41 (16.3%), other drugs 12 (4.8%), unknown 50 (19.8%). Clinical forms: mild in 127 (50.4%), moderate 101 (40.1%) and severe 24 (9.5%). No deaths were registered with ADI. Average period of hospitalization: accidental ADI 3.33±2.54 (1–9), voluntary ADI 3.28±1.24 (1–6) days. Conclusions ADI represented 39.1% of the total number of acute intoxications; 61.1% of ADI were accidental. Most ADI were caused by AINS, methoclopramid, anti-epileptics. ADI prevailed in females, in urban children, both in voluntary and accidental ADI. The clinical forms were mostly mild.