1131 Cardiovascular and Hormonal Responses to Hypoxic Stress in the Preterm Piglet

Background and Aims Immature control of the cardiovascular system may be a contributing factor to poor cardiovascular function and associated increases in mortality and morbidity in preterm infants. This study aimed to assess cardiovascular and hormonal responses to a mild hypoxic stress in newborn...

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Bibliographic Details
Published in:Archives of disease in childhood 2012-10, Vol.97 (Suppl 2), p.A324-A324
Main Authors: Eiby, YA, Staunton, MP, Wright, LL, Lumbers, ER, Colditz, PB, Lingwood, BE
Format: Article
Language:English
Subjects:
Blood pressure
Cardiovascular system
Feedback (Response)
Hypoxia
Pregnancy
Swine
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Summary:Background and Aims Immature control of the cardiovascular system may be a contributing factor to poor cardiovascular function and associated increases in mortality and morbidity in preterm infants. This study aimed to assess cardiovascular and hormonal responses to a mild hypoxic stress in newborn piglets. Methods Piglets were delivered by C-section at 97 and 113 days of gestation (term≈115d). An additional preterm group was exposed to maternal glucocorticoid treatment. Changes in mean arterial blood pressure (MAP), skin blood flow and plasma concentrations of adrenalin, noradrenalin, angiotensin II and cortisol were measured in response to acute hypoxia (4% O2 for 20min). Results Preterm piglets were less likely to exhibit a mature cardiovascular compensatory response to hypoxia (increased MAP and reduced skin blood flow) than term piglets. Plasma adrenalin and noradrenalin concentrations at the end of hypoxia were increased in all groups and were 2–3 fold higher in preterm pigs than in term pigs (P
ISSN:0003-9888
1468-2044
DOI:10.1136/archdischild-2012-302724.1131