G428(P) Markers of endothelial dysfunction in newborn babies from the group of high perinatal risk

• Published in: Archives of disease in childhood 2014-04, Vol.99 (Suppl 1), p.A179-A179
• Main Authors: Todorova, AS, Berezhanskaya, SB, Lukyanova, EA, Kaushanskaya, EY, Chernykh, AG, Afonin, AA
• Format: Article
• Language: English
• Subjects: Anatomy; Central nervous system; Hypoxia; Neonates; Pathology
• ISSN: 0003-9888; 1468-2044
• DOI: 10.1136/archdischild-2014-306237.410

Aims To determine the role of membrane protein, thrombomodulin, in the prediction of endothelial dysfunction in newborn babies from the group of high perinatal risk. Methods 39 children from the group of a high perinatal risk were examined, among them there were 18 newborn babies without manifestation of neurological pathology and 21 newborn babies with cerebral ischaemia of the 2nd and 3rd degrees of severity and its consequences in the first year of life. The content of thrombomodulin (CD141) in the blood serum was determined by means of immunoenzyme method with the help of commercial kits of the company CD 141 ELISAKIT at birth and over the time of neonatal period (days 7–14; month 1). Results In the newborns with severe cerebral pathology in the early neonatal period we detected a significant increase of the level of specific membrane protein – thrombomodulin, namely, the receptor of thrombin (CD141), which in a normal state is connected with a membrane of endotheliocytes, for which reason it is almost absent in the circulation. A significant increase in the concentration of thrombomodulin in the blood flow of children with cerebral ischaemia at birth without any tendency towards decreasing in the late neonatal period indicate the presence of endothelial dysfunction and disturbance of endothelium contribution to the maintenance of cerebral blood flow and intravascular hemostasis. Conclusion The level of thrombomodulin in the blood of newborn babies can be used as a marker of cerebral endothelial dysfunction and its early detection must promote the improvement of diagnostics and the effectiveness of therapy for children with hypoxic-ischaemic injury of the central nervous system.