Integrated genomic analyses identify KDM1A 's role in cell proliferation via modulating E2F signaling activity and associate with poor clinical outcome in oral cancer

Highlights • Oral cancer is the sixth most common cancer in the developing countries. • Elevated expression of KDM1A in oral cancers promotes cell proliferation. • KDM1A knockdown decreases E2F signaling in oral cancer cell lines. • KDM1A promotes cell proliferation via modulating E2F signaling. • E...

Full description

Saved in:
Bibliographic Details
Published in:Cancer letters 2015-10, Vol.367 (2), p.162-172
Main Authors: Narayanan, Sathiya Pandi, Singh, Smriti, Gupta, Amit, Yadav, Sandhya, Singh, Shree Ram, Shukla, Sanjeev
Format: Article
Language:English
Subjects:
Biomarkers
Cell growth
Clinical outcomes
Deoxyribonucleic acid
DNA
DNA methylation
Epigenetics
Gene expression
Hematology, Oncology and Palliative Medicine
Medical prognosis
Ontology
Oral cancer
Studies
Transcription factors
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • Oral cancer is the sixth most common cancer in the developing countries. • Elevated expression of KDM1A in oral cancers promotes cell proliferation. • KDM1A knockdown decreases E2F signaling in oral cancer cell lines. • KDM1A promotes cell proliferation via modulating E2F signaling. • Elevated KDM1A expression is associated with poor clinical outcome in oral cancer.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2015.07.022