Integrated genomic analyses identify KDM1A 's role in cell proliferation via modulating E2F signaling activity and associate with poor clinical outcome in oral cancer

Highlights • Oral cancer is the sixth most common cancer in the developing countries. • Elevated expression of KDM1A in oral cancers promotes cell proliferation. • KDM1A knockdown decreases E2F signaling in oral cancer cell lines. • KDM1A promotes cell proliferation via modulating E2F signaling. • E...

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Published in:Cancer letters 2015-10, Vol.367 (2), p.162-172
Main Authors: Narayanan, Sathiya Pandi, Singh, Smriti, Gupta, Amit, Yadav, Sandhya, Singh, Shree Ram, Shukla, Sanjeev
Format: Article
Language:English
Subjects:
Biomarkers
Cell growth
Clinical outcomes
Deoxyribonucleic acid
DNA
DNA methylation
Epigenetics
Gene expression
Hematology, Oncology and Palliative Medicine
Medical prognosis
Ontology
Oral cancer
Studies
Transcription factors
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container_end_page 172
container_issue 2
container_start_page 162
container_title Cancer letters
container_volume 367
creator Narayanan, Sathiya Pandi
Singh, Smriti
Gupta, Amit
Yadav, Sandhya
Singh, Shree Ram
Shukla, Sanjeev
description Highlights • Oral cancer is the sixth most common cancer in the developing countries. • Elevated expression of KDM1A in oral cancers promotes cell proliferation. • KDM1A knockdown decreases E2F signaling in oral cancer cell lines. • KDM1A promotes cell proliferation via modulating E2F signaling. • Elevated KDM1A expression is associated with poor clinical outcome in oral cancer.
doi_str_mv 10.1016/j.canlet.2015.07.022
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subjects Biomarkers
Cell growth
Clinical outcomes
Deoxyribonucleic acid
DNA
DNA methylation
Epigenetics
Gene expression
Hematology, Oncology and Palliative Medicine
Medical prognosis
Ontology
Oral cancer
Studies
Transcription factors
title Integrated genomic analyses identify KDM1A 's role in cell proliferation via modulating E2F signaling activity and associate with poor clinical outcome in oral cancer
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