The COMT Val158Met Polymorphism and Temporal Lobe Volumetry in Patients with Schizophrenia and Healthy Adults

Recent imaging studies suggest that increased anxiety associated with the met allele may be the result of relatively increased amygdala and hippocampal activation (Drabant, 2006; Smolka, 2005). [...]using data from a multi-center study, we tested the hypothesis that amygdala and hippocampal volume i...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2009-07, Vol.47, p.S161-S161
Main Authors: Ehrlich, S., Morrow, E.E., Wallace, S.R., Naylor, M.G, Bockholt, H.J., Holt, D.J., Lundquist, A.P., Yendiki, A., Roffman, J.L., Ho, B.C., White, T., Manoach, D.S., Clark, V.P., Calhoun, V.D., Gollub, R.L.
Format: Article
Language:English
Subjects:
Genotype & phenotype
Schizophrenia
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Summary:Recent imaging studies suggest that increased anxiety associated with the met allele may be the result of relatively increased amygdala and hippocampal activation (Drabant, 2006; Smolka, 2005). [...]using data from a multi-center study, we tested the hypothesis that amygdala and hippocampal volume is influenced by the COMT val158met polymorphism in healthy subjects and patients with schizophrenia. General linear models including val allele load as an additive effect and controlling for age, estimated intracranial volume, gender and site were run for the four different brain regions of interest and whole brain volume as a control measure.
ISSN:1053-8119
1095-9572
DOI:10.1016/S1053-8119(09)71702-1