Ionic Liquid Catalyzed One-Pot Synthesis of 2H-Pyridazino[1,2-a]indazole-1,6,9(11H)-triones Via Three-Component Reaction under Solvent-Free Conditions

2H‐Pyridazino[1,2‐a]indazole‐1,6,9(11H)‐triones were synthesized through one‐pot, three‐component condesation of aldehydes, maleic hydrazide, and dimedone using a green and inexpensive Brönsted acidic ionic liquid 1‐methyl‐2‐pyrrolidinone hydrosulfate ([Hnmp]HSO4) as catalyst under solvent‐free cond...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2016-11, Vol.53 (6), p.2061-2065
Main Authors: Ding, Maohua, Guo, Hongyun
Format: Article
Language:English
Online Access:Get full text
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Summary:2H‐Pyridazino[1,2‐a]indazole‐1,6,9(11H)‐triones were synthesized through one‐pot, three‐component condesation of aldehydes, maleic hydrazide, and dimedone using a green and inexpensive Brönsted acidic ionic liquid 1‐methyl‐2‐pyrrolidinone hydrosulfate ([Hnmp]HSO4) as catalyst under solvent‐free conditions. The method provided several advantages such as milder conditions, shorter reaction time, high yields, and environmentally benign procedure.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.1736