Design, facile synthesis, molecular docking, DNA binding, and cytotoxic activity of polythiophene and polythiophene-titanium(IV) phosphate nanocomposite

The present article reports the synthesis of polythiophene-titanium(IV) phosphate nanocomposite (PTh-TiP) by a simple in situ titanium(IV) phosphate assisted chemical polymerization of thiophene. The structure and formation of polymer and its nanocomposite was confirmed by FTIR, XRD, FE-SEM, TEM, an...

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Bibliographic Details
Published in:International journal of polymeric materials 2017-03, Vol.66 (5), p.243-257
Main Authors: Baig, Umair, Gondal, M. A., Alam, Md. Fazle, Alam, Mahboob, Wani, Waseem A., Younus, Hina
Format: Article
Language:English
Subjects:
Chromatin
Cytotoxic activity
Cytotoxicity
Deoxyribonucleic acid
DNA
DNA binding
molecular docking
Nanocomposites
polymer
polymeric nanocomposite
toxicity
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Summary:The present article reports the synthesis of polythiophene-titanium(IV) phosphate nanocomposite (PTh-TiP) by a simple in situ titanium(IV) phosphate assisted chemical polymerization of thiophene. The structure and formation of polymer and its nanocomposite was confirmed by FTIR, XRD, FE-SEM, TEM, and TGA techniques. UV-Visible, fluorescence, and circular dichroism spectrophotometry as well as viscometry and DNA melting studies were used to investigate the DNA binding of PTh and PTh-TiP with calf-thymus DNA. The anticancer activities of these materials against MCF-7 and MDA-MB- 231 cancer cells indicated both PTh and PTh-TiP are moderately active, with the latter being more active than the former.
ISSN:0091-4037
1563-535X
DOI:10.1080/00914037.2016.1201825