Design, facile synthesis, molecular docking, DNA binding, and cytotoxic activity of polythiophene and polythiophene-titanium(IV) phosphate nanocomposite

The present article reports the synthesis of polythiophene-titanium(IV) phosphate nanocomposite (PTh-TiP) by a simple in situ titanium(IV) phosphate assisted chemical polymerization of thiophene. The structure and formation of polymer and its nanocomposite was confirmed by FTIR, XRD, FE-SEM, TEM, an...

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Published in:International journal of polymeric materials 2017-03, Vol.66 (5), p.243-257
Main Authors: Baig, Umair, Gondal, M. A., Alam, Md. Fazle, Alam, Mahboob, Wani, Waseem A., Younus, Hina
Format: Article
Language:English
Subjects:
Chromatin
Cytotoxic activity
Cytotoxicity
Deoxyribonucleic acid
DNA
DNA binding
molecular docking
Nanocomposites
polymer
polymeric nanocomposite
toxicity
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creator Baig, Umair
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description The present article reports the synthesis of polythiophene-titanium(IV) phosphate nanocomposite (PTh-TiP) by a simple in situ titanium(IV) phosphate assisted chemical polymerization of thiophene. The structure and formation of polymer and its nanocomposite was confirmed by FTIR, XRD, FE-SEM, TEM, and TGA techniques. UV-Visible, fluorescence, and circular dichroism spectrophotometry as well as viscometry and DNA melting studies were used to investigate the DNA binding of PTh and PTh-TiP with calf-thymus DNA. The anticancer activities of these materials against MCF-7 and MDA-MB- 231 cancer cells indicated both PTh and PTh-TiP are moderately active, with the latter being more active than the former.
doi_str_mv 10.1080/00914037.2016.1201825
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source Taylor and Francis Science and Technology Collection
subjects Chromatin
Cytotoxic activity
Cytotoxicity
Deoxyribonucleic acid
DNA
DNA binding
molecular docking
Nanocomposites
polymer
polymeric nanocomposite
toxicity
title Design, facile synthesis, molecular docking, DNA binding, and cytotoxic activity of polythiophene and polythiophene-titanium(IV) phosphate nanocomposite
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