Value and perspectives of proton radiation therapy for limited stage prostate cancer

This review article will focus on clinical results and limitations of proton beam irradiation. Possible technological, biological and medical perspectives will be addressed. A total of 911 patients with limited stage prostate cancer were treated with proton beam irradiation at Loma Linda University...

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Bibliographic Details
Published in:Strahlentherapie und Onkologie 2000, Vol.176 (1), p.3-8
Main Authors: SCHULTE, R. W, SLATER, J. D, ROSSI, C. J, SLATER, J. M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cancer therapies
Dose Fractionation
Follow-Up Studies
Genital system. Mammary gland
Humans
Male
Medical sciences
Multivariate Analysis
Neoplasm Staging
Prostate cancer
Prostate-Specific Antigen - blood
Prostatic Neoplasms - mortality
Prostatic Neoplasms - pathology
Prostatic Neoplasms - radiotherapy
Protons - therapeutic use
Radiotherapy, High-Energy - adverse effects
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Retrospective Studies
Survival Rate
Time Factors
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Summary:This review article will focus on clinical results and limitations of proton beam irradiation. Possible technological, biological and medical perspectives will be addressed. A total of 911 patients with limited stage prostate cancer were treated with proton beam irradiation at Loma Linda University between 1991 and 1996. Endpoints of this evaluation were biochemically no evidence of disease survival (bNED) as well as acute and late treatment-related toxicity. The bNED survival rate was 82% at 5 years. Among 870 patients evaluable for late toxicity the following late effects were observed: Grade 3/4: 0%, Grade 2 rectal: 3.5% and bladder: 5.4%. Despite relatively short follow-up times it seems justified to conclude that proton beam irradiation of prostate cancer can improve bNED rates by 10% and decrease Grade 2 late effects by more than 10%. There were no Grade 3 and 4 late effects.
ISSN:0179-7158
1439-099X
DOI:10.1007/pl00002302