Successful renal transplantation in a patient with cold agglutinin disease

Cold agglutinin disease is a rare cause of acute graft loss after renal transplantation. A 71‐year‐old female with end stage renal failure was diagnosed to have cold agglutinin disease when investigated for recurrent clotting of hemodialysis circuits. Kidney transplantation was a major challenge due...

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Bibliographic Details
Published in:Journal of clinical apheresis 2017-02, Vol.32 (1), p.56-58
Main Authors: Vilayur, Eswari, Trevillian, Paul, Heer, Munish
Format: Article
Language:English
Subjects:
Aged
Anemia, Hemolytic, Autoimmune - therapy
Autoantibodies - blood
cold agglutinin disease
Delayed Graft Function
Female
Graft Survival
Humans
Kidney Failure, Chronic - therapy
Kidney Transplantation - methods
Kidney Transplantation - standards
plasma exchange
Plasma Exchange - methods
renal transplantation
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Summary:Cold agglutinin disease is a rare cause of acute graft loss after renal transplantation. A 71‐year‐old female with end stage renal failure was diagnosed to have cold agglutinin disease when investigated for recurrent clotting of hemodialysis circuits. Kidney transplantation was a major challenge due to unavoidable exposure of the transplant kidney to cold temperatures. Large volume plasma exchange given pre‐transplant and infusion of warm saline prior to anastomosis resulted in successful renal transplantation with good graft function despite initial delayed graft function. This challenging case illustrates the complete removal of cold agglutinin antibodies with therapeutic large volume plasma exchange. J. Clin. Apheresis 32:56–58, 2017. © 2016 Wiley Periodicals, Inc.
ISSN:0733-2459
1098-1101
DOI:10.1002/jca.21460