Quercetin and Vitamin C Mitigate Cobalt Chloride-Induced Hypertension through Reduction in Oxidative Stress and Nuclear Factor Kappa Beta (NF-Kb) Expression in Experimental Rat Model

• Published in: Biological trace element research 2017-02, Vol.175 (2), p.347-359
• Main Authors: Ajibade, Temitayo Olabisi, Oyagbemi, Ademola Adetokunbo, Omobowale, Temidayo Olutayo, Asenuga, Ebunoluwa Racheal, Adigun, Kabirat Oluwaseun
• Format: Article
• Language: English
• Subjects: animal models; Animals; antioxidant activity; Antioxidants; ascorbic acid; Ascorbic Acid - pharmacology; Bioavailability; Biochemistry; Biomedical and Life Sciences; Biotechnology; Blood pressure; Cardiovascular system; chlorides; Cobalt; Cobalt - toxicity; Flavonoids; Gene Expression Regulation - drug effects; glutathione; glutathione peroxidase; Hydrogen peroxide; Hypertension; Hypertension - chemically induced; Hypertension - metabolism; Hypertension - prevention & control; immunohistochemistry; Laboratory animals; Life Sciences; Male; malondialdehyde; NF-kappa B - metabolism; Nitric oxide; Nutrition; Oncology; Oxidative stress; Oxidative Stress - drug effects; protective effect; quercetin; Quercetin - pharmacology; Rats; Rats, Wistar; toxicity; transcription factor NF-kappa B; Vitamin C
• ISSN: 0163-4984; 1559-0720
• DOI: 10.1007/s12011-016-0773-5

The objective of the present work was to evaluate the toxic effects of cobalt chloride, a potent oxidative stress-inducing chemical, at 650 ppm in rats and the protective effect of quercetin and/or vitamin C against the cobalt chloride-induced toxicity. Thirty rats were randomly selected, and assigned to one of five groups: control, cobalt chloride, cobalt chloride + quercetin, cobalt chloride + vitamin C and cobalt chloride + quercetin + vitamin C. The exposure of rats to cobalt chloride led to a significant increase ( p