New Iridoid Glucosides from Caryopteris incana (Thunb.) Miq. and Their [alpha]-Glucosidase Inhibitory Activities

In our continued investigations of the plant Caryopteris incana, five new iridoid glucosides 1-5, including two cis-trans-isomers, 3 and 4, along with six known compounds 6-11, were isolated from the n-butyl alcohol (n-BuOH) soluble fraction of whole dried material of Caryopteris incana. Their struc...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2016-12, Vol.21 (12), p.1749
Main Authors: Mao, Xu-Dong, Chou, Gui-Xin, Zhao, Sen-Miao, Zhang, Cheng-Gang
Format: Article
Language:English
Subjects:
Alcohol
Diabetes
Spectrum analysis
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Summary:In our continued investigations of the plant Caryopteris incana, five new iridoid glucosides 1-5, including two cis-trans-isomers, 3 and 4, along with six known compounds 6-11, were isolated from the n-butyl alcohol (n-BuOH) soluble fraction of whole dried material of Caryopteris incana. Their structures were established by a combination of spectroscopic techniques, including 1D and 2D NMR and high resolution electrospray ionization mass spectroscopy (HR-ESI-MS). Furthermore, all isolates were evaluated for their yeast [alpha]-glucosidase inhibitory effects. Among these compounds, 4-8 and 10 exhibited potent inhibition of [alpha]-glucosidase.
ISSN:1420-3049
DOI:10.3390/molecules21121749