Polycaprolactone/Amino-[beta]-Cyclodextrin Inclusion Complex Prepared by an Electrospinning Technique

• Published in: Polymers 2016-11, Vol.8 (11), p.395
• Main Authors: Moyers-Montoya, Edgar, García-Casillas, Perla, Vargas-Requena, Claudia, Escobedo-Gonzalez, Rene, Martel-Estrada, Santos-Adriana, Martínez-Perez, Carlos A
• Format: Article
• Language: English
• ISSN: 2073-4360
• DOI: 10.3390/polym8110395

Electrospun scaffolds of neat poly-[straight epsilon]-caprolactone (PCL), poly-[straight epsilon]-caprolactone/[beta]-cyclodextrin inclusion complex (PCL/[beta]-CD) and poly-[straight epsilon]-caprolactone amino derivative inclusion complex (PCL/[beta]-CD-NH2) were prepared by the electrospinning technique. The obtained mats were analyzed by a theoretical model using the Hartree-Fock method with an STO-3G basis set, and characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), Fourier transform infrared spectroscopy-attenuated total reflectance (FTIR-ATR), differential scanning calorimetry (DSC), confocal-Raman spectroscopy, proton nuclear magnetic resonance (1HNMR) and contact angle measure (CA). Different mixtures of solvents, such as dimethylformamide (DMF)-tetrahydrofuran (THF), dichlormethane (DCM)-dimethyl sulfoxide (DMSO) and 2,2,2-Trifluoroethanol (TFE), were tested in the fiber preparation. The results indicate that electrospun nanofibers have a pseudorotaxane structure and when it was prepared using a 2,2,2-Trifluoroethanol (TFE) as solvent, the nanofibers were electrospun well and, with the other solvents, fibers present defects such as molten fibers and bead-like defects into the fiber structure. This work provides insights into the design of PCL/[beta]-CD-NH2 based scaffolds that could have applications in the biomedical field.