Triphenylphosphine (PPh3) Catalyzed Erlenmeyer Reaction for Azlactones under Solvent‐free Conditions

This study presents triphenylphosphine catalyzed process for the synthesis of azlactones and their derivatives using hippuric and substituted aromatic aldehydes. The methodology also found to be effective for the synthesis of azlactones from 5‐(2,6‐dichlorophenyl)‐3‐methyl‐1,2‐oxazol‐4‐yl carbonyl a...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2017-01, Vol.54 (1), p.429-435
Main Authors: Punna Rao, Alapati Mohan Lakshmi, Sridhar Rao, Abburi, Saratchandra Babu, Mukkamala, Krishnaji Rao, M.
Format: Article
Language:English
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Summary:This study presents triphenylphosphine catalyzed process for the synthesis of azlactones and their derivatives using hippuric and substituted aromatic aldehydes. The methodology also found to be effective for the synthesis of azlactones from 5‐(2,6‐dichlorophenyl)‐3‐methyl‐1,2‐oxazol‐4‐yl carbonyl amino acetic acid and offers several advantages such as solvent‐free conditions, excellent yields, simple procedure, mild conditions, and reduced environmental consequences.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.2600