MicroRNA hsa-miR-4674 in Hemolysis-Free Blood Plasma Is Associated with Distant Metastases of Prostatic Cancer

We analyzed microRNA profile in hemolysis-free blood plasma of patients with prostatic cancer. The metastatic form of prostatic cancer was found to be associated with increased levels of hsa-miR-22-3p, hsa-miR-663a, and hsa-miR-4674 in comparison with non-metastatic form. Common candidate target gen...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2016-05, Vol.161 (1), p.112-115
Main Authors: Knyazev, E. N., Samatov, T. R., Fomicheva, K. A., Nyushko, K. M., Alekseev, B. Ya, Shkurnikov, M. Yu
Format: Article
Language:English
Subjects:
Analysis
Biomarkers, Tumor - blood
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer metastasis
Case-Control Studies
Cell Biology
DNA microarrays
Health savings accounts
Hemolysis
Humans
Internal Medicine
Laboratory Medicine
Male
MicroRNA
MicroRNAs - blood
Neoplasm Metastasis
Pathology
Prostatic Neoplasms, Castration-Resistant - blood
Prostatic Neoplasms, Castration-Resistant - pathology
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Summary:We analyzed microRNA profile in hemolysis-free blood plasma of patients with prostatic cancer. The metastatic form of prostatic cancer was found to be associated with increased levels of hsa-miR-22-3p, hsa-miR-663a, and hsa-miR-4674 in comparison with non-metastatic form. Common candidate target genes of these microRNA include JUNB , KMT2A , and XPO6 .
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-016-3358-6