Anti-inflammatory effect of selenium nanoparticles on the inflammation induced in irradiated rats

• Published in: Canadian journal of physiology and pharmacology 2017-02, Vol.95 (2), p.101-110
• Main Authors: El-Ghazaly, M.A, Fadel, N, Rashed, E, El-Batal, A, Kenawy, S.A
• Format: Article
• Language: English
• Subjects: air pouch; Analgesics - therapeutic use; Animals; Anti-Inflammatory Agents - therapeutic use; carrageenan; carraghénine; Dinoprostone; gamma-irradiation; Health aspects; Inflammation; Inflammation - drug therapy; Inflammation - metabolism; irradiation gamma; Leukocyte Count; Male; Nanoparticles; Nanoparticles - therapeutic use; nanoparticules de sélénium; Nitrates - metabolism; Nitrites - metabolism; nociceptive threshold; Pain Measurement - drug effects; paw edema; Physiological aspects; poche d’air; Rats; Rodents; Selenium; Selenium - therapeutic use; selenium nanoparticles; seuil nociceptif; Thiobarbituric Acid Reactive Substances - metabolism; Toxicity; Tumor Necrosis Factor-alpha - metabolism; Whole-Body Irradiation - adverse effects; œdème de la patte
• ISSN: 0008-4212; 1205-7541
• DOI: 10.1139/cjpp-2016-0183

Selenium (Se) has been reported to possess anti-inflammatory properties, but its bioavailability and toxicity are considerable limiting factors. The present study aimed to investigate the possible anti-inflammatory and analgesic effects of selenium nanoparticles (Nano-Se) on inflammation induced in irradiated rats. Paw volume and nociceptive threshold were measured in carrageenan-induced paw edema and hyperalgesia model. Leukocytic count, tumor necrosis factor-α (TNF-α), prostaglandin E 2 (PGE 2 ), thiobarbituric acid reactive substances (TBAR), and total nitrate/nitrite (NOx) were estimated in the exudate collected from 6 day old air pouch model. Irradiated rats were exposed to 6 Gy gamma (γ)-irradiation. Nano-Se were administered orally in a dose of 2.55 mg/kg once before carrageenan injection in the first model and twice in the second model. The paw volume but not the nociceptive response produced by carrageenan in irradiated rats was higher than that induced in non-irradiated rats. Nano-Se were effective in reducing the paw volume in non-irradiated and irradiated rats but it did not alter the nociceptive threshold. The inflammation induced in irradiated rats increased all the estimated parameters in the exudate whereas; Nano-Se decreased their elevation in non-irradiated and irradiated rats. Nano-Se possess a potential anti-inflammatory activity on inflammation induced in irradiated rats.