Acute and sub-acute toxicity studies on the effect of Senna alata in Swiss Albino mice

Senna alata has attracted the attention of many researchers due to its numerous medicinal properties. This study aims to test the acute and sub-acute toxicity of its leaf extracts in Swiss albino mice. Studies were carried out with a fixed dose of 1,000, 2,000, and 3,000 mg/kg body weight through or...

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Bibliographic Details
Published in:Cogent biology 2016-12, Vol.2 (1), p.1272166
Main Authors: Roy, S., Ukil, B., Lyndem, L.M.
Format: Article
Language:English
Subjects:
Acute toxicity
Albinism
Body weight
Dosage
extracts
Kidneys
Leaves
mice
Mortality
nontoxic
Oral administration
Plant extracts
Senna alata
Spleen
Toxicity
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Summary:Senna alata has attracted the attention of many researchers due to its numerous medicinal properties. This study aims to test the acute and sub-acute toxicity of its leaf extracts in Swiss albino mice. Studies were carried out with a fixed dose of 1,000, 2,000, and 3,000 mg/kg body weight through oral administration daily. Signs of toxicity in terms of behavior and mortality were noted after every two hours till 24 h of administration for acute toxicity and further administration of extracts till 15 days to analyze the physical, biochemical, hematological parameters, and histopathological studies in liver, kidney, and spleen for sub-acute study. The highest dose administered did not produce mortality or changes in the general behavior of the test animals. All parameters were unaltered throughout the study. The present study revealed no obvious toxicity in mice treated with S. alata. These results indicate the safety of the oral administration of leaf extract.
ISSN:2331-2025
2331-2025
DOI:10.1080/23312025.2016.1272166